E333Sequestrant · Stabiliser
Calcium citrates
What the research shows
PrototypeNo concerns
none of the findings here link it to harm
4 health findings on this page, 3 in people · See the findings
A calcium-based additive also used in supplements.
It is used to preserve food and sometimes for flavour.
Written from English Wikipedia1
- Vegan
- Vegetarian
- EU permitted
What research says
Studies in people
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Benefit
Calcium absorption after stomach surgery2
In people who had gastric bypass, calcium citrate got more calcium into the blood than calcium carbonate did.
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No harm found
Bone health after stomach surgery3
In people who had gastric bypass, calcium citrate did not lower parathyroid hormone more than calcium carbonate.
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Benefit
Bone breakdown4
In young women, calcium citrate was absorbed well and lowered a hormone that drives bone breakdown.
Animal and lab studies only
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Open question
Bone loss in space7
In animal studies, calcium citrate with collagen peptides did not stop bone loss, though it helped some bone structure.
Study type not stated
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Open question
Heart risk from calcium6
Scientists do not yet know whether calcium citrate raises heart risk, though it briefly lifts blood calcium more than dairy does.
How it’s made and used
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Blood calcium levels5
Calcium citrate raised blood calcium for hours after each dose, and this did not lessen after 3 months.
The signal at the top counts the findings in people and in animal and lab studies. A concern in studies of people outranks animal and lab studies, and “No concerns” needs at least two findings in people. Findings whose study type is not stated are shown but not counted. This page is a reference, not medical advice. It describes what regulators and published research say. Talk to a doctor or dietitian about your own diet.
Regulatory status
Checked Sep 2026-
United States Permitted FDA 21 CFR 184.1195
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European Union Permitted EUR-Lex Reg. (EC) 1333/2008
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United Kingdom Permitted FSA retained EU law
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Canada Permitted Health Canada · Emulsifying Gelling Stabilizing Thickening Agents
Status reflects the named register on the date checked. It is not a safety rating.
How we checkProducts
The 6 most-scanned of 1,171 products on Open Food Facts that list calcium citrates.
- Natur mit Kokosnuss alpro · 0,5 kg 4 additives
- Croissance réduit en sucre Jaouda · 500 ml 1 additive
- Nature aux Amandes - Végétal soja & amande Alpro · 0.5 kg 5 additives
- Purified Drinking Water Kirkland Signature · 500 mL 2 additives
- Hipro façon stracciatella Danone · 2 x 160 g 7 additives
- Almond No Sugars Acti Leaf · 1 litre 1 additive
References
- 1Calcium citrate. Wikipedia. Accessed September 26, 2026.
- 2Tondapu P, Provost D, Adams-Huet B, Sims T, Chang C, Sakhaee K. Comparison of the absorption of calcium carbonate and calcium citrate after Roux-en-Y gastric bypass. Obes Surg. 2009;19(9):1256-61. doi:10.1007/s11695-009-9850-6
- 3Ring Madsen L, Espersen R, Rejnmark L, Richelsen B. Effect of calcium citrate vs calcium carbonate on elevated parathyroid hormone after Roux-en-Y gastric bypass. A double-blinded, randomized trial. Clin Endocrinol (Oxf). 2018;89(6):734-741. doi:10.1111/cen.13836
- 4Karp HJ, Ketola ME, Lamberg-Allardt CJ. Acute effects of calcium carbonate, calcium citrate and potassium citrate on markers of calcium and bone metabolism in young women. Br J Nutr. 2009;102(9):1341-7. doi:10.1017/S0007114509990195
- 5Bristow SM, Gamble GD, Stewart A, et al. Acute and 3-month effects of microcrystalline hydroxyapatite, calcium citrate and calcium carbonate on serum calcium and markers of bone turnover: a randomised controlled trial in postmenopausal women. Br J Nutr. 2014;112(10):1611-20. doi:10.1017/S0007114514002785
- 6Bristow SM, Gamble GD, Stewart A, Kalluru R, Horne AM, Reid IR. Acute effects of calcium citrate with or without a meal, calcium-fortified juice and a dairy product meal on serum calcium and phosphate: a randomised cross-over trial. Br J Nutr. 2015;113(10):1585-94. doi:10.1017/S000711451500080X
- 7Liu J, Wang J, Guo Y. Effect of Collagen Peptide, Alone and in Combination with Calcium Citrate, on Bone Loss in Tail-Suspended Rats. Molecules. 2020;25(4). doi:10.3390/molecules25040782