E578Sequestrant

Calcium gluconate

What the research shows

No concerns

none of the findings here link it to harm

A calcium supplement made from gluconic acid.

It is used as a mineral supplement and medication.1

  • Vegan
  • Vegetarian
  • EU permitted

What research says

Studies in people

The signal at the top counts the findings in people and in animal and lab studies. A concern in studies of people outranks animal and lab studies, and “No concerns” needs at least one finding in people. When most findings in people point one way, the page leans that way (“Mostly”), and every finding is still shown. Findings whose study type is not stated are shown but not counted. This page is a reference, not medical advice. It describes what regulators and published research say. Talk to a doctor or dietitian about your own diet.

What expert reviews concluded

Expert panels that weigh all the research. Shown for context: the signal at the top does not count them.

Regulatory status

Checked Sep 2026

Status reflects the named register on the date checked. It is not a safety rating.

How we check

Products

The 6 most-scanned of 95 products on Open Food Facts that list calcium gluconate.

  • Apple eve juice no sugar added variety Apple & Eve 1 additive
  • Calcium Magnesium Zinc Nature's Bounty · 100 caplets 2 additives
  • Fruit Punch 4 Juice Blend From Concentrate With Added Ingredients Apple & Eve · 200 ml 2 additives
  • Juice Cocktail From Concentrate 2 additives
  • Rennet Custard Mix, Chocolate Junket 1 additive
  • Juice Langer Juice Company Inc. 1 additive

References

  1. 1Calcium gluconate. Wikipedia. Accessed September 26, 2026. CC BY-SA 4.0.
  2. 2Krause M, Keller J, Beil B, et al. Calcium gluconate supplementation is effective to balance calcium homeostasis in patients with gastrectomy. Osteoporos Int. 2015;26(3):987-95. doi:10.1007/s00198-014-2965-1