E578Sequestrant
Calcium gluconate
What the research shows
No concerns
none of the findings here link it to harm
A calcium supplement made from gluconic acid.
It is used as a mineral supplement and medication.1
- Vegan
- Vegetarian
- EU permitted
What research says
Studies in people
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Benefit
Bone strength after stomach surgery2
In five people who had stomach surgery and enough vitamin D, calcium gluconate alone raised bone density over at least six months.
The signal at the top counts the findings in people and in animal and lab studies. A concern in studies of people outranks animal and lab studies, and “No concerns” needs at least one finding in people. When most findings in people point one way, the page leans that way (“Mostly”), and every finding is still shown. Findings whose study type is not stated are shown but not counted. This page is a reference, not medical advice. It describes what regulators and published research say. Talk to a doctor or dietitian about your own diet.
What expert reviews concluded
Expert panels that weigh all the research. Shown for context: the signal at the top does not count them.
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UN and WHO food additive experts (JECFA), 1998
No daily limit needed (“ADI not specified”, JECFA’s term for very low toxicity).
Regulatory status
Checked Sep 2026-
United States Permitted FDA 21 CFR 184.1199
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European Union Permitted EUR-Lex Reg. (EC) 1333/2008
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United Kingdom Permitted FSA retained EU law
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Canada Permitted Health Canada · Emulsifying Gelling Stabilizing Thickening Agents
Status reflects the named register on the date checked. It is not a safety rating.
How we checkProducts
The 6 most-scanned of 95 products on Open Food Facts that list calcium gluconate.
- Apple eve juice no sugar added variety Apple & Eve 1 additive
- Calcium Magnesium Zinc Nature's Bounty · 100 caplets 2 additives
- Fruit Punch 4 Juice Blend From Concentrate With Added Ingredients Apple & Eve · 200 ml 2 additives
- Juice Cocktail From Concentrate 2 additives
- Rennet Custard Mix, Chocolate Junket 1 additive
- Juice Langer Juice Company Inc. 1 additive
References
- 1Calcium gluconate. Wikipedia. Accessed September 26, 2026. CC BY-SA 4.0.
- 2Krause M, Keller J, Beil B, et al. Calcium gluconate supplementation is effective to balance calcium homeostasis in patients with gastrectomy. Osteoporos Int. 2015;26(3):987-95. doi:10.1007/s00198-014-2965-1