Caseinate

What the research shows

Concerning

in animal and lab studies only

A protein found in milk.

It helps mix ingredients that normally separate, like oil and water.1

  • Not vegan
  • Vegetarian

What research says

Studies in people

  • Benefit

    Blood sugar after meals2

    In people, sodium caseinate drunk with carbs lowered blood sugar peaks, but no more than whey protein did.

  • No harm found

    Blood sugar and appetite3

    In people, caseinate in a drink gave the same blood sugar, insulin and appetite response whether or not it was treated.

Animal and lab studies only

  • Benefit

    Mineral absorption from food5

    In lab studies, iron and zinc bound to succinylated sodium caseinate were taken up better by cells than plain mineral salts.

  • Benefit

    Vitamin A absorption6

    In lab studies, caseinate helped protect vitamin A during digestion and increased how much cells took up.

  • Concern

    Gut barrier strength8

    In lab studies, caseinate digested with lactose sugar helped gut cells less than plain caseinate did.

Single cases of misuse or overdose

One person or one incident, such as an accidental overdose or a mistake in a kitchen or factory. They are real, but a single case does not show what happens at normal amounts, so the signal does not count them.

  • Hidden milk in food4

    A person with cow's milk allergy had a severe reaction after eating a hot dog that contained caseinate.

How it’s made and used

The signal at the top counts the findings in people and in animal and lab studies. A concern in studies of people outranks animal and lab studies, and “No concerns” needs at least one finding in people. When most findings in people point one way, the page leans that way (“Mostly”), and every finding is still shown. Findings whose study type is not stated are shown but not counted. This page is a reference, not medical advice. It describes what regulators and published research say. Talk to a doctor or dietitian about your own diet.

Products

The 6 most-scanned of 7,584 products on Open Food Facts that list caseinate.

  • COFFEE MATE AVELLANA NESTLE · 500 ml 3 additives
  • Sour Cream & Onion Pringles 7 additives
  • Protein Bar sabor a Brownie SPORTYFEEL · 135 g (3 x 45 g) 5 additives
  • Garden Salsa Flavored Sun Chips Sun Chips 3 additives
  • Harvest Cheddar Sun Chips · 7 oz (198.4 g) 3 additives
  • Grenade Oreo Grenade · 60 g 8 additives

References

  1. 1Casein. Wikipedia. Accessed September 26, 2026. CC BY-SA 4.0.
  2. 2Hoefle AS, Bangert AM, Stamfort A, et al. Metabolic responses of healthy or prediabetic adults to bovine whey protein and sodium caseinate do not differ. J Nutr. 2015;145(3):467-75. doi:10.3945/jn.114.199190
  3. 3Juvonen KR, Lille ME, Laaksonen DE, et al. Crosslinking with transglutaminase does not change metabolic effects of sodium caseinate in model beverage in healthy young individuals. Nutr J. 2012;11:35. doi:10.1186/1475-2891-11-35
  4. 4Kocabaş CN, Sekerel BE. Cow's milk allergic patients should be informed of the sources of caseinate. Turk J Pediatr. 2003;45(2):165-6.
  5. 5Shilpashree BG, Arora S, Kapila S, Sharma V. Physicochemical characterization of mineral (iron/zinc) bound caseinate and their mineral uptake in Caco-2 cells. Food Chem. 2018;257:101-111. doi:10.1016/j.foodchem.2018.02.157
  6. 6Rana S, Arora S, Gupta C, Kapila S. Effect of sodium caseinate and vitamin A complexation on bioaccessibility and bioavailability of vitamin A in Caco-2 cells. Food Res Int. 2019;121:910-918. doi:10.1016/j.foodres.2019.01.019
  7. 7Havenaar R, de Jong A, Koenen ME, et al. Digestibility of transglutaminase cross-linked caseinate versus native caseinate in an in vitro multicompartmental model simulating young child and adult gastrointestinal conditions. J Agric Food Chem. 2013;61(31):7636-44. doi:10.1021/jf402824u
  8. 8Shi J , Zhao XH. Influence of the Maillard-type caseinate glycation with lactose on the intestinal barrier activity of the caseinate digest in IEC-6 cells. Food Funct. 2019;10(4):2010-2021. doi:10.1039/c8fo02607f