Cyanocobalamin

What the research shows

Prototype

Conflicting

studies in people disagree or haven’t settled it

2 health findings on this page · See the findings

A form of vitamin B12.

It treats and prevents vitamin B12 deficiency.

Written from English Wikipedia1

  • Vegan
  • Vegetarian

What research says

Studies in people

  • Benefit

    Oral treatment for anemia2

    In people with pernicious anemia, taking cyanocobalamin by mouth improved vitamin B12 levels within a month.

  • Concern

    Skin bacteria and acne3

    In one of ten people studied, vitamin B12 supplements changed skin bacteria and acne appeared.

Study type not stated

  • Benefit

    low vitamin levels4

    Vitamin B12 is needed for DNA and energy, and low levels are common in vegetarians and older people.

How it’s made and used

The signal at the top counts the findings in people and in animal and lab studies. A concern in studies of people outranks animal and lab studies, and “No concerns” needs at least two findings in people. Findings whose study type is not stated are shown but not counted. This page is a reference, not medical advice. It describes what regulators and published research say. Talk to a doctor or dietitian about your own diet.

Products

The 6 most-scanned of 5,171 products on Open Food Facts that list cyanocobalamin.

  • Nutritional Yeast Flakes Engevita · 100 g 0 additives
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  • Chocolate Huel · 1 Bottle 3 additives
  • Organic Unsweetened Almond Non-Dairy Beverage Vanilla Kirkland Signature · 946 ml 3 additives
  • Soya Unsweetened plant based Lidl · 1000 ml 1 additive
  • Vanilla Protein Shake Premier Protein · 11 ounces 7 additives

References

  1. 1Cyanocobalamin. Wikipedia. Accessed September 26, 2026.
  2. 2Lacombe V, Vinatier E, Roquin G, et al. Oral vitamin B12 supplementation in pernicious anemia: a prospective cohort study. Am J Clin Nutr. 2024;120(1):217-224. doi:10.1016/j.ajcnut.2024.05.019
  3. 3Kang D, Shi B, Erfe MC, Craft N, Li H. Vitamin B12 modulates the transcriptome of the skin microbiota in acne pathogenesis. Sci Transl Med. 2015;7(293):293ra103. doi:10.1126/scitranslmed.aab2009
  4. 4O'Leary F, Samman S. Vitamin B12 in health and disease. Nutrients. 2010;2(3):299-316. doi:10.3390/nu2030299
  5. 5Watanabe F. Vitamin B12 sources and bioavailability. Exp Biol Med (Maywood). 2007;232(10):1266-74. doi:10.3181/0703-MR-67