Fortified wheat flour

What the research shows

Prototype

No concerns

none of the findings here link it to harm

5 health findings on this page, 4 in people · See the findings

Flour with iron and B vitamins added.

It puts back nutrients lost when flour is refined.

Written from English Wikipedia1

What research says

Studies in people

  • Benefit

    Iron levels in the blood2

    Eating iron-fortified wheat flour raised iron levels and lowered anaemia in people across many countries.

  • Benefit

    Birth defects in babies3

    In Chile, adding folic acid to wheat flour cut serious birth defects of the brain and spine by about half.

  • Open question

    Immune function in women4

    In women with low iron, fortified wheat flour with iron and prebiotics changed levels of immune proteins called immunoglobulins.

  • Benefit

    Vitamin and mineral levels in women and children5

    In women and children in Cameroon, fortified wheat flour was linked to higher iron, zinc, folate and vitamin B-12 levels.

  • Benefit

    Cleft lip and palate in babies6

    Hospital stays for cleft lip and palate in babies fell after Chile started adding folic acid to wheat flour.

Study type not stated

  • Benefit

    Vitamin and mineral shortfalls7

    Fortified wheat flour adds vitamins and minerals that many people, especially children and women, do not get enough of.

  • Benefit

    Iron and anaemia8

    Fortified wheat flour may lower anaemia risk, but scientists do not yet know whether it helps other health outcomes.

  • Benefit

    Calcium intake shortfall9

    Adding calcium to wheat flour could help many people get closer to the calcium they need.

How it’s made and used

The signal at the top counts the findings in people and in animal and lab studies. A concern in studies of people outranks animal and lab studies, and “No concerns” needs at least two findings in people. Findings whose study type is not stated are shown but not counted. This page is a reference, not medical advice. It describes what regulators and published research say. Talk to a doctor or dietitian about your own diet.

References

  1. 1Enriched flour. Wikipedia. Accessed September 26, 2026.
  2. 2Sadighi J, Nedjat S, Rostami R. Systematic review and meta-analysis of the effect of iron-fortified flour on iron status of populations worldwide. Public Health Nutr. 2019;22(18):3465-3484. doi:10.1017/S1368980019002179
  3. 3Cortés F, Mellado C, Pardo RA, Villarroel LA, Hertrampf E. Wheat flour fortification with folic acid: changes in neural tube defects rates in Chile. Am J Med Genet A. 2012;158A(8):1885-90. doi:10.1002/ajmg.a.35430
  4. 4Rizwan Ahmad AM, Ahmed W, Iqbal S, Mushtaq MH, Anis RA. Iron and prebiotic fortified flour improves the immune function of iron deficient women of childbearing age. Pak J Pharm Sci. 2020;33(1(Supplementary)):253-261.
  5. 5Engle-Stone R, Nankap M, Ndjebayi AO, et al. Iron, Zinc, Folate, and Vitamin B-12 Status Increased among Women and Children in Yaoundé and Douala, Cameroon, 1 Year after Introducing Fortified Wheat Flour. J Nutr. 2017;147(7):1426-1436. doi:10.3945/jn.116.245076
  6. 6Paulos A, Pino P, Cavada G, Lagos C, Broussain V, Hasbún A. [Cleft lip/palate and flour fortification with folic acid in Chile]. Rev Med Chil. 2016;144(8):1012-1019. doi:10.4067/S0034-98872016000800008
  7. 7Cardoso RVC, Fernandes Â, Gonzaléz-Paramás AM, Barros L, Ferreira ICFR. Flour fortification for nutritional and health improvement: A review. Food Res Int. 2019;125:108576. doi:10.1016/j.foodres.2019.108576
  8. 8Field MS, Mithra P, Peña-Rosas JP. Wheat flour fortification with iron and other micronutrients for reducing anaemia and improving iron status in populations. Cochrane Database Syst Rev. 2021;1(1):CD011302. doi:10.1002/14651858.CD011302.pub3
  9. 9Cormick G, Romero IB, Puchulu MB, et al. A simulation study to improve calcium intake through wheat flour fortification. Public Health Nutr. 2024;27(1):e159. doi:10.1017/S1368980024001228
  10. 10Centers for Disease Control and Prevention (CDC). Trends in wheat-flour fortification with folic acid and iron--worldwide, 2004 and 2007. MMWR Morb Mortal Wkly Rep. 2008;57(1):8-10.