Glucose-fructose syrup

What the research shows

Prototype

Concerning

in animal and lab studies only

2 of 2 health findings on this page · See the findings

A sweetener made from corn.

It sweetens processed foods, cereals and soft drinks.

Written from English Wikipedia1

What research says

Animal and lab studies only

  • Concern

    Cancer risk3

    In animal studies, glucose-fructose syrup sped up tumour growth in colorectal, breast and melanoma models, even without obesity.

  • Concern

    Male fertility4

    In animal studies, long-term high-fructose corn syrup lowered sperm count and changed testicle tissue in rats.

Study type not stated

  • Open question

    Blood sugar and fats2

    In studies, glucose-fructose syrup and table sugar changed blood sugar, fats, and appetite the same.

The signal at the top counts the findings in people and in animal and lab studies. A concern in studies of people outranks animal and lab studies, and “No concerns” needs at least two findings in people. Findings whose study type is not stated are shown but not counted. This page is a reference, not medical advice. It describes what regulators and published research say. Talk to a doctor or dietitian about your own diet.

References

  1. 1High-fructose corn syrup. Wikipedia. Accessed September 26, 2026.
  2. 2Sobel LL, Dalby E. Sugar or high fructose corn syrup-what should nurses teach patients and families? Worldviews Evid Based Nurs. 2014;11(2):126-32. doi:10.1111/wvn.12027
  3. 3Aoyagi T, Ohira G, Hayano K, Martin O, Takabe K. High-Fructose Corn Syrup on Inflammation and Cancer. World J Oncol. 2025;16(6):531-537. doi:10.14740/wjon2652
  4. 4Aslankoc R, Ozmen O. The effects of high-fructose corn syrup consumption on testis physiopathology-The ameliorative role of melatonin. Andrologia. 2019;51(8):e13327. doi:10.1111/and.13327