Glucose-fructose syrup
What the research shows
PrototypeConcerning
in animal and lab studies only
2 of 2 health findings on this page · See the findings
A sweetener made from corn.
It sweetens processed foods, cereals and soft drinks.
Written from English Wikipedia1
What research says
Animal and lab studies only
-
Concern
Cancer risk3
In animal studies, glucose-fructose syrup sped up tumour growth in colorectal, breast and melanoma models, even without obesity.
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Concern
Male fertility4
In animal studies, long-term high-fructose corn syrup lowered sperm count and changed testicle tissue in rats.
Study type not stated
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Open question
Blood sugar and fats2
In studies, glucose-fructose syrup and table sugar changed blood sugar, fats, and appetite the same.
The signal at the top counts the findings in people and in animal and lab studies. A concern in studies of people outranks animal and lab studies, and “No concerns” needs at least two findings in people. Findings whose study type is not stated are shown but not counted. This page is a reference, not medical advice. It describes what regulators and published research say. Talk to a doctor or dietitian about your own diet.
References
- 1High-fructose corn syrup. Wikipedia. Accessed September 26, 2026.
- 2Sobel LL, Dalby E. Sugar or high fructose corn syrup-what should nurses teach patients and families? Worldviews Evid Based Nurs. 2014;11(2):126-32. doi:10.1111/wvn.12027
- 3Aoyagi T, Ohira G, Hayano K, Martin O, Takabe K. High-Fructose Corn Syrup on Inflammation and Cancer. World J Oncol. 2025;16(6):531-537. doi:10.14740/wjon2652
- 4Aslankoc R, Ozmen O. The effects of high-fructose corn syrup consumption on testis physiopathology-The ameliorative role of melatonin. Andrologia. 2019;51(8):e13327. doi:10.1111/and.13327