E422Humectant · Thickener

Glycerol

What the research shows

Conflicting

studies in people disagree

A sweet-tasting liquid that is found in animal fats and vegetable oils.

It is used as a sweetener and as a humectant.1

Also used on skin: Glycerol (skin)

  • May not be vegan
  • May not be vegetarian
  • EU permitted

What research says

Studies in people

  • Benefit

    Water retention after dehydration2

    In men, glycerol taken by mouth with fluids helped the body hold onto more water after dehydration.

  • Open question

    Fluid retention and stamina3

    In studies, glycerol helped people hold onto more water than plain water did, but whether it boosts stamina is still unclear.

  • Concern

    Gut acrolein formation4

    Gut bacteria can turn glycerol from food into acrolein, and people who ate more glycerol had more acrolein markers in their urine.

  • Open question

    Body temperature during exercise5

    In people, drinking glycerol with water before exercising in heat led to more sweating and a lower body temperature.

Animal and lab studies only

Study type not stated

  • Open question

    Impurities in a food additive6

    Glycerol samples held very low levels of arsenic, lead, mercury and cadmium, and experts said the current limits should be lowered.

The signal at the top counts the findings in people and in animal and lab studies. A concern in studies of people outranks animal and lab studies, and “No concerns” needs at least one finding in people. When most findings in people point one way, the page leans that way (“Mostly”), and every finding is still shown. Findings whose study type is not stated are shown but not counted. This page is a reference, not medical advice. It describes what regulators and published research say. Talk to a doctor or dietitian about your own diet.

Regulatory status

Checked Sep 2026

Status reflects the named register on the date checked. It is not a safety rating.

How we check

Products

The 6 most-scanned of 13,630 products on Open Food Facts that list glycerol.

  • Protein Nut Bar Fruit & Chocolate Nature Valley · 160 g 4 additives
  • Wraps Multigrains Gruma · 370 g 4 additives
  • Barrette Proteiche al Caramello Salato Nature Valley · 40 g 3 additives
  • 20 madeleines longues aux œufs frais Le Ster · 250 g 6 additives
  • Buldak Spicy Ramen Samyang · 4.94 oz (140 g) 14 additives
  • Bounty 2er Bounty · 57 g 2 additives

References

  1. 1Glycerol. Wikipedia. Accessed September 26, 2026. CC BY-SA 4.0.
  2. 2van Rosendal SP, Strobel NA, Osborne MA, Fassett RG, Coombes JS. Hydration and endocrine responses to intravenous fluid and oral glycerol. Scand J Med Sci Sports. 2015;25 Suppl 1:112-25. doi:10.1111/sms.12367
  3. 3Goulet ED, Aubertin-Leheudre M, Plante GE, Dionne IJ. A meta-analysis of the effects of glycerol-induced hyperhydration on fluid retention and endurance performance. Int J Sport Nutr Exerc Metab. 2007;17(4):391-410. doi:10.1123/ijsnem.17.4.391
  4. 4Schwab C, Lang H, Stegmüller S, et al. Microbial Transformation of Dietary Glycerol Contributes to Intestinal Acrolein Formation and Urinary Excretion. Mol Nutr Food Res. 2025;69(24):e70289. doi:10.1002/mnfr.70289
  5. 5Lyons TP, Riedesel ML, Meuli LE, Chick TW. Effects of glycerol-induced hyperhydration prior to exercise in the heat on sweating and core temperature. Med Sci Sports Exerc. 1990;22(4):477-83.
  6. 6Younes M, Aquilina G, Castle L, et al. Follow-up of the re-evaluation of glycerol (E 422) as a food additive. EFSA J. 2022;20(6):e07353. doi:10.2903/j.efsa.2022.7353
  7. 7Zhang J, Lacroix C, Wortmann E, et al. Gut microbial beta-glucuronidase and glycerol/diol dehydratase activity contribute to dietary heterocyclic amine biotransformation. BMC Microbiol. 2019;19(1):99. doi:10.1186/s12866-019-1483-x