E422Humectant · Thickener
Glycerol
What the research shows
Conflicting
studies in people disagree
A sweet-tasting liquid that is found in animal fats and vegetable oils.
It is used as a sweetener and as a humectant.1
Also used on skin: Glycerol (skin)
- May not be vegan
- May not be vegetarian
- EU permitted
What research says
Studies in people
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Benefit
Water retention after dehydration2
In men, glycerol taken by mouth with fluids helped the body hold onto more water after dehydration.
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Open question
Fluid retention and stamina3
In studies, glycerol helped people hold onto more water than plain water did, but whether it boosts stamina is still unclear.
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Concern
Gut acrolein formation4
Gut bacteria can turn glycerol from food into acrolein, and people who ate more glycerol had more acrolein markers in their urine.
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Open question
Body temperature during exercise5
In people, drinking glycerol with water before exercising in heat led to more sweating and a lower body temperature.
Animal and lab studies only
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Benefit
Meat compound detoxification7
Gut bacteria used glycerol to turn a meat compound into a less harmful one.
Study type not stated
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Open question
Impurities in a food additive6
Glycerol samples held very low levels of arsenic, lead, mercury and cadmium, and experts said the current limits should be lowered.
The signal at the top counts the findings in people and in animal and lab studies. A concern in studies of people outranks animal and lab studies, and “No concerns” needs at least one finding in people. When most findings in people point one way, the page leans that way (“Mostly”), and every finding is still shown. Findings whose study type is not stated are shown but not counted. This page is a reference, not medical advice. It describes what regulators and published research say. Talk to a doctor or dietitian about your own diet.
Regulatory status
Checked Sep 2026-
United States Permitted FDA 21 CFR 182.1320
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European Union Permitted EUR-Lex Reg. (EC) 1333/2008
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United Kingdom Permitted FSA retained EU law
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Canada Permitted Health Canada · Other Accepted Uses
Status reflects the named register on the date checked. It is not a safety rating.
How we checkProducts
The 6 most-scanned of 13,630 products on Open Food Facts that list glycerol.
- Protein Nut Bar Fruit & Chocolate Nature Valley · 160 g 4 additives
- Wraps Multigrains Gruma · 370 g 4 additives
- Barrette Proteiche al Caramello Salato Nature Valley · 40 g 3 additives
- 20 madeleines longues aux œufs frais Le Ster · 250 g 6 additives
- Buldak Spicy Ramen Samyang · 4.94 oz (140 g) 14 additives
- Bounty 2er Bounty · 57 g 2 additives
References
- 1Glycerol. Wikipedia. Accessed September 26, 2026. CC BY-SA 4.0.
- 2van Rosendal SP, Strobel NA, Osborne MA, Fassett RG, Coombes JS. Hydration and endocrine responses to intravenous fluid and oral glycerol. Scand J Med Sci Sports. 2015;25 Suppl 1:112-25. doi:10.1111/sms.12367
- 3Goulet ED, Aubertin-Leheudre M, Plante GE, Dionne IJ. A meta-analysis of the effects of glycerol-induced hyperhydration on fluid retention and endurance performance. Int J Sport Nutr Exerc Metab. 2007;17(4):391-410. doi:10.1123/ijsnem.17.4.391
- 4Schwab C, Lang H, Stegmüller S, et al. Microbial Transformation of Dietary Glycerol Contributes to Intestinal Acrolein Formation and Urinary Excretion. Mol Nutr Food Res. 2025;69(24):e70289. doi:10.1002/mnfr.70289
- 5Lyons TP, Riedesel ML, Meuli LE, Chick TW. Effects of glycerol-induced hyperhydration prior to exercise in the heat on sweating and core temperature. Med Sci Sports Exerc. 1990;22(4):477-83.
- 6Younes M, Aquilina G, Castle L, et al. Follow-up of the re-evaluation of glycerol (E 422) as a food additive. EFSA J. 2022;20(6):e07353. doi:10.2903/j.efsa.2022.7353
- 7Zhang J, Lacroix C, Wortmann E, et al. Gut microbial beta-glucuronidase and glycerol/diol dehydratase activity contribute to dietary heterocyclic amine biotransformation. BMC Microbiol. 2019;19(1):99. doi:10.1186/s12866-019-1483-x