Lactiplantibacillus

What the research shows

No concerns

none of the findings here link it to harm

A group of bacteria that make lactic acid.12

What research says

Studies in people

  • Benefit

    Iron absorption3

    Lactiplantibacillus plantarum Lp299v may help the body take in more iron from food, studies suggest.

  • Benefit

    Gut comfort and iron4

    Lactiplantibacillus plantarum 299v may ease gas and belly pain in IBS and help the body absorb iron.

  • Benefit

    Gut and immune health5

    Some Lactiplantibacillus plantarum strains may ease gut symptoms, skin allergies and vaginal problems, but effects differ by strain.

  • Benefit

    Gut comfort in children6

    In children with Tourette syndrome, Lactiplantibacillus plantarum PS128 eased stomach pain, though tics stayed about the same.

  • Benefit

    Immune defense7

    In people, heat-treated Lactiplantibacillus plantarum LM1004 boosted natural killer cell activity and white blood cell counts.

Animal and lab studies only

  • Benefit

    Blood sugar control8

    In animal studies, Lactiplantibacillus plantarum improved blood sugar and insulin, but scientists do not yet know if it helps people.

  • Benefit

    Parkinson's disease symptoms9

    In animal studies, Lactiplantibacillus plantarum eased movement problems in mice with Parkinson's-like symptoms.

  • Benefit

    Gut protection during chemo10

    In animal studies, Lactiplantibacillus plantarum strains eased gut damage from a chemo drug but did not stop weight loss.

  • Benefit

    Gut inflammation11

    In animal studies, Lactiplantibacillus plantarum LP15-1 eased gut inflammation, but scientists do not yet know if the germ changes cause this.

  • Benefit

    Liver inflammation from viruses12

    In animal studies, Lactiplantibacillus plantarum CRL1506 lessened liver damage from a virus-like trigger, but a changed version did not.

  • Benefit

    Blood pressure and organ injury13

    In animal studies, Lactiplantibacillus plantarum T4-1 lowered blood pressure and reduced organ injury in mice on a high-salt diet.

  • Benefit

    Kidney health and uric acid14

    In mice, Lactiplantibacillus strains lowered uric acid and eased kidney scarring, but we don't know if this works in people.

The signal at the top counts the findings in people and in animal and lab studies. A concern in studies of people outranks animal and lab studies, and “No concerns” needs at least one finding in people. When most findings in people point one way, the page leans that way (“Mostly”), and every finding is still shown. Findings whose study type is not stated are shown but not counted. This page is a reference, not medical advice. It describes what regulators and published research say. Talk to a doctor or dietitian about your own diet.

Products

The 6 most-scanned of 137 products on Open Food Facts that list lactiplantibacillus.

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References

  1. 1Lactiplantibacillus: ingredient taxonomy entry. Open Food Facts.
  2. 2Lactiplantibacillus. Wikipedia. Accessed September 30, 2026. CC BY-SA 4.0.
  3. 3Webb B, Farrell M, Montelius C, Önning G. Probiotics and iron bioavailability: mechanisms, clinical evidence, and translational applications-a comprehensive review of the probiotic strain Lactiplantibacillus plantarum 299v (LP299V®). Front Nutr. 2026;13:1905459. doi:10.3389/fnut.2026.1905459
  4. 4Nordström EA, Teixeira C, Montelius C, Jeppsson B, Larsson N. Lactiplantibacillus plantarum 299v (LP299V(®)): three decades of research. Benef Microbes. 2021;12(5):441-465. doi:10.3920/BM2020.0191
  5. 5Chatsirisakul O, Leenabanchong N, Siripaopradit Y, Chang CW, Buhngamongkol P, Pongpirul K. Strain-Specific Therapeutic Potential of Lactiplantibacillus plantarum: A Systematic Scoping Review. Nutrients. 2025;17(7). doi:10.3390/nu17071165
  6. 6Chang YT, Hong SY, Lin SS, Lin CH, Wu PY, Chou IC. Adjunctive psychobiotic Lactiplantibacillus plantarum PS128 ameliorates gastrointestinal comorbidities and alters circulating miRNAs and gut microbiota in children with Tourette syndrome: a randomized controlled trial. Food Funct. 2026;17(18):8101-8113. doi:10.1039/d6fo03349k
  7. 7Kim S, Seo H, Kim TR, et al. Microbiome-Modulating Effects of Heat-Treated Lactiplantibacillus plantarum LM1004 and Its Enhancement of NK Cell Activity: Evidence from a Clinical Trial and a Simulated Human Intestinal Microbiome Ecosystem. J Microbiol Biotechnol. 2026;36:e2604046. doi:10.4014/jmb.2604.04046
  8. 8Kumar A, Kumar V, Pramanik J, et al. Lactiplantibacillus Plantarum as a Complementary Approach for Diabetes Treatment and Management. Curr Nutr Rep. 2025;14(1):72. doi:10.1007/s13668-025-00664-x
  9. 9Chen WL, Deng FS, Tsai YC. Lactiplantibacillus plantarum as a Psychobiotic Strategy Targeting Parkinson's Disease: A Review and Mechanistic Insights. Nutrients. 2025;17(19). doi:10.3390/nu17193047
  10. 10Coelho-Rocha ND, de Jesus LCL, Barroso FAL, et al. Evaluation of Probiotic Properties of Novel Brazilian Lactiplantibacillus plantarum Strains. Probiotics Antimicrob Proteins. 2023;15(1):160-174. doi:10.1007/s12602-022-09978-6
  11. 11Fan S, Zheng Y, Duan T, et al. Lactiplantibacillus plantarum LP15-1 regulates intestinal innate immunity via suppressing the NF-κB pathway to modulate M cell differentiation. Free Radic Biol Med. 2026;255:319-332. doi:10.1016/j.freeradbiomed.2026.07.036
  12. 12Lorenzo Pisarello MJ, Baillo AA, Elean M, et al. Lactiplantibacillus plantarum CRL1506 ameliorates poly(I:C)-induced acute liver injury through cell wall-dependent modulation of inflammatory and antiviral immune responses. Food Funct. 2026;17(18):8322-8331. doi:10.1039/d6fo01160h
  13. 13Jia T, Dai W, Deng Z, Guo J, Yan Z, Xu H. Unlocking Probiotic Potential: Lactiplantibacillus plantarum Targets ACE to Mitigate High-Salt Diet-Induced Multiorgan Injury. J Agric Food Chem. 2026;74(22):17511-17534. doi:10.1021/acs.jafc.6c03155
  14. 14Mo Q, Qin M, Liang H, et al. Lactiplantibacillus pentosus JWN01 and Lactiplantibacillus plantarum JWN02 attenuate renal fibrosis and pathological autophagy in hyperuricemic nephropathy via gut-kidney axis. Food Res Int. 2026;228:118376. doi:10.1016/j.foodres.2026.118376