Lactiplantibacillus
What the research shows
No concerns
none of the findings here link it to harm
What research says
Studies in people
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Benefit
Iron absorption3
Lactiplantibacillus plantarum Lp299v may help the body take in more iron from food, studies suggest.
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Benefit
Gut comfort and iron4
Lactiplantibacillus plantarum 299v may ease gas and belly pain in IBS and help the body absorb iron.
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Benefit
Gut and immune health5
Some Lactiplantibacillus plantarum strains may ease gut symptoms, skin allergies and vaginal problems, but effects differ by strain.
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Benefit
Gut comfort in children6
In children with Tourette syndrome, Lactiplantibacillus plantarum PS128 eased stomach pain, though tics stayed about the same.
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Benefit
Immune defense7
In people, heat-treated Lactiplantibacillus plantarum LM1004 boosted natural killer cell activity and white blood cell counts.
Animal and lab studies only
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Benefit
Blood sugar control8
In animal studies, Lactiplantibacillus plantarum improved blood sugar and insulin, but scientists do not yet know if it helps people.
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Benefit
Parkinson's disease symptoms9
In animal studies, Lactiplantibacillus plantarum eased movement problems in mice with Parkinson's-like symptoms.
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Benefit
Gut protection during chemo10
In animal studies, Lactiplantibacillus plantarum strains eased gut damage from a chemo drug but did not stop weight loss.
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Benefit
Gut inflammation11
In animal studies, Lactiplantibacillus plantarum LP15-1 eased gut inflammation, but scientists do not yet know if the germ changes cause this.
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Benefit
Liver inflammation from viruses12
In animal studies, Lactiplantibacillus plantarum CRL1506 lessened liver damage from a virus-like trigger, but a changed version did not.
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Benefit
Blood pressure and organ injury13
In animal studies, Lactiplantibacillus plantarum T4-1 lowered blood pressure and reduced organ injury in mice on a high-salt diet.
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Benefit
Kidney health and uric acid14
In mice, Lactiplantibacillus strains lowered uric acid and eased kidney scarring, but we don't know if this works in people.
The signal at the top counts the findings in people and in animal and lab studies. A concern in studies of people outranks animal and lab studies, and “No concerns” needs at least one finding in people. When most findings in people point one way, the page leans that way (“Mostly”), and every finding is still shown. Findings whose study type is not stated are shown but not counted. This page is a reference, not medical advice. It describes what regulators and published research say. Talk to a doctor or dietitian about your own diet.
Products
The 6 most-scanned of 137 products on Open Food Facts that list lactiplantibacillus.
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References
- 1Lactiplantibacillus: ingredient taxonomy entry. Open Food Facts.
- 2Lactiplantibacillus. Wikipedia. Accessed September 30, 2026. CC BY-SA 4.0.
- 3Webb B, Farrell M, Montelius C, Önning G. Probiotics and iron bioavailability: mechanisms, clinical evidence, and translational applications-a comprehensive review of the probiotic strain Lactiplantibacillus plantarum 299v (LP299V®). Front Nutr. 2026;13:1905459. doi:10.3389/fnut.2026.1905459
- 4Nordström EA, Teixeira C, Montelius C, Jeppsson B, Larsson N. Lactiplantibacillus plantarum 299v (LP299V(®)): three decades of research. Benef Microbes. 2021;12(5):441-465. doi:10.3920/BM2020.0191
- 5Chatsirisakul O, Leenabanchong N, Siripaopradit Y, Chang CW, Buhngamongkol P, Pongpirul K. Strain-Specific Therapeutic Potential of Lactiplantibacillus plantarum: A Systematic Scoping Review. Nutrients. 2025;17(7). doi:10.3390/nu17071165
- 6Chang YT, Hong SY, Lin SS, Lin CH, Wu PY, Chou IC. Adjunctive psychobiotic Lactiplantibacillus plantarum PS128 ameliorates gastrointestinal comorbidities and alters circulating miRNAs and gut microbiota in children with Tourette syndrome: a randomized controlled trial. Food Funct. 2026;17(18):8101-8113. doi:10.1039/d6fo03349k
- 7Kim S, Seo H, Kim TR, et al. Microbiome-Modulating Effects of Heat-Treated Lactiplantibacillus plantarum LM1004 and Its Enhancement of NK Cell Activity: Evidence from a Clinical Trial and a Simulated Human Intestinal Microbiome Ecosystem. J Microbiol Biotechnol. 2026;36:e2604046. doi:10.4014/jmb.2604.04046
- 8Kumar A, Kumar V, Pramanik J, et al. Lactiplantibacillus Plantarum as a Complementary Approach for Diabetes Treatment and Management. Curr Nutr Rep. 2025;14(1):72. doi:10.1007/s13668-025-00664-x
- 9Chen WL, Deng FS, Tsai YC. Lactiplantibacillus plantarum as a Psychobiotic Strategy Targeting Parkinson's Disease: A Review and Mechanistic Insights. Nutrients. 2025;17(19). doi:10.3390/nu17193047
- 10Coelho-Rocha ND, de Jesus LCL, Barroso FAL, et al. Evaluation of Probiotic Properties of Novel Brazilian Lactiplantibacillus plantarum Strains. Probiotics Antimicrob Proteins. 2023;15(1):160-174. doi:10.1007/s12602-022-09978-6
- 11Fan S, Zheng Y, Duan T, et al. Lactiplantibacillus plantarum LP15-1 regulates intestinal innate immunity via suppressing the NF-κB pathway to modulate M cell differentiation. Free Radic Biol Med. 2026;255:319-332. doi:10.1016/j.freeradbiomed.2026.07.036
- 12Lorenzo Pisarello MJ, Baillo AA, Elean M, et al. Lactiplantibacillus plantarum CRL1506 ameliorates poly(I:C)-induced acute liver injury through cell wall-dependent modulation of inflammatory and antiviral immune responses. Food Funct. 2026;17(18):8322-8331. doi:10.1039/d6fo01160h
- 13Jia T, Dai W, Deng Z, Guo J, Yan Z, Xu H. Unlocking Probiotic Potential: Lactiplantibacillus plantarum Targets ACE to Mitigate High-Salt Diet-Induced Multiorgan Injury. J Agric Food Chem. 2026;74(22):17511-17534. doi:10.1021/acs.jafc.6c03155
- 14Mo Q, Qin M, Liang H, et al. Lactiplantibacillus pentosus JWN01 and Lactiplantibacillus plantarum JWN02 attenuate renal fibrosis and pathological autophagy in hyperuricemic nephropathy via gut-kidney axis. Food Res Int. 2026;228:118376. doi:10.1016/j.foodres.2026.118376