Margarine
What the research shows
Conflicting
studies in people disagree
What research says
Studies in people
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Benefit
Cholesterol and heart risk3
Margarine with added plant stanols or sterols lowers LDL cholesterol only a little, and not in everyone.
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Open question
Blood vessel health4
In people, rapeseed-sterol margarine changed two blood markers tied to vessel health, but what this means is not yet known.
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Benefit
Heart attack risk5
In women, swapping butter or stick margarine for tub margarine was linked to fewer heart attacks.
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No harm found
Childhood body size6
In people, vitamin-D from fortified margarine during pregnancy showed no link to children's weight at age 7.
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Benefit
Pregnancy blood pressure risk7
Women whose mothers ate margarine fortified with extra vitamin D while pregnant had lower odds of pre-eclampsia later.
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Benefit
Asthma in children8
In children, eating margarine once or twice a week was linked to less asthma and wheezing, but the cause is not known.
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Open question
Blood cholesterol and heart risk9
In people, soft margarines lowered cholesterol and hard high-trans margarines gave no benefit over butter.
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Concern
Heart health10
Margarine once contained trans fats linked to higher heart disease risk, so makers now cut them down.
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Benefit
Cholesterol levels11
In people, eating a tub of margarine with added phytosterols weekly lowered total and LDL cholesterol.
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Benefit
Belly fat12
People eating margarine with MCT fats lost more belly, under-skin and deep fat than with regular margarine.
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Open question
Cholesterol response14
Whether sitostanol-supplemented margarine lowers cholesterol varies between people, and a blood test may predict who responds.
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Open question
Blood antioxidant levels16
Eating margarine with added vitamins C and E raised the levels of these vitamins in people's blood.
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Concern
Heart attack risk in women17
In Italian women, eating more margarine was linked to a higher risk of heart attack.
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Concern
Allergies in children18
In children, eating margarine was linked to more allergic sensitization and runny nose, mostly in boys.
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Concern
Blood fat levels19
In people, eating margarine with trans fats changed blood fat levels, but butter and margarine looked different.
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Open question
Blood clotting and heart risk21
In healthy people, margarine made with chemically rearranged vegetable fats changed blood clotting markers only slightly compared with regular margarine.
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Open question
Birth weight in babies22
Babies born after margarine was fortified with vitamin D weighed slightly more or less, but the change was small and inconsistent.
Animal and lab studies only
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Open question
Heart health fats23
Margarine made with chia oil had more omega-3 fats and no trans fats than regular margarine.
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Benefit
Fat digestion24
In lab studies, margarine made with cottonseed and palm oils released more free fatty acids, which may make it easier to digest.
How it’s made and used
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Cholesterol levels in people13
In people using margarine, swapping it for rapeseed or olive oil changed cholesterol levels.
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Stool sterol levels15
Eating margarine with added vegetable oil sterols made people pass more sterols in their stools.
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Recommended dose shortfall20
In people at high heart risk, few used phytosterol-enriched margarine, and most users took less than the recommended amount.
The signal at the top counts the findings in people and in animal and lab studies. A concern in studies of people outranks animal and lab studies, and “No concerns” needs at least one finding in people. When most findings in people point one way, the page leans that way (“Mostly”), and every finding is still shown. Findings whose study type is not stated are shown but not counted. This page is a reference, not medical advice. It describes what regulators and published research say. Talk to a doctor or dietitian about your own diet.
Products
The 6 most-scanned of 4,279 products on Open Food Facts that list margarine.
- Cantuccini Sondey · 500 g 4 additives
- Superfood Oat Bites Cocoa & Orange Lidl · 4 x 30 g 1 additive
- Le Sfoglie Puff Pastry Italiamo · 225 g e 2 additives
- Cantuccini mit Pistazien Deluxe · 200 g 4 additives
- Cookies Schär · 6 x 35 g 5 additives
- Ready Rolled Puff Pastry Sheet Jus Rol · 320 g 3 additives
References
- 1Margarine: ingredient taxonomy entry. Open Food Facts.
- 2Margarine. Wikipedia. Accessed September 26, 2026. CC BY-SA 4.0.
- 3Doggrell SA. Lowering LDL cholesterol with margarine containing plant stanol/sterol esters: is it still relevant in 2011? Complement Ther Med. 2011;19(1):37-46. doi:10.1016/j.ctim.2010.12.004
- 4Heggen E, Kirkhus B, Pedersen JI, Tonstad S. Effects of margarine enriched with plant sterol esters from rapeseed and tall oils on markers of endothelial function, inflammation and hemostasis. Scand J Clin Lab Invest. 2015;75(2):189-92. doi:10.3109/00365513.2014.992040
- 5Liu Q, Rossouw JE, Roberts MB, et al. Theoretical Effects of Substituting Butter with Margarine on Risk of Cardiovascular Disease. Epidemiology. 2017;28(1):145-156. doi:10.1097/EDE.0000000000000557
- 6Jensen CB, Gamborg M, Berentzen TL, Sørensen TI, Heitmann BL. Prenatal exposure to vitamin-D from fortified margarine and milk and body size at age 7 years. Eur J Clin Nutr. 2015;69(10):1169-75. doi:10.1038/ejcn.2015.55
- 7Stougaard M, Damm P, Frederiksen P, Jacobsen R, Heitmann BL. Exposure to vitamin D from fortified margarine during fetal life and later risk of pre-eclampsia: the D-tect Study. Public Health Nutr. 2018;21(4):721-731. doi:10.1017/S1368980017003135
- 8Emrani AS, Sasanfar B, Nafei Z, Behniafard N, Salehi-Abargouei A. Association between Butter, Margarine, and Olive Oil Intake and Asthma Symptoms among School Children: Result from a Large-Scale Cross-Sectional Study. J Immunol Res. 2023;2023:2884630. doi:10.1155/2023/2884630
- 9Zock PL, Katan MB. Butter, margarine and serum lipoproteins. Atherosclerosis. 1997;131(1):7-16. doi:10.1016/s0021-9150(96)06063-7
- 10Griguol Chulich VI, León-Camacho M, Vicario Romero IM. [Margarine's trans-fatty acid composition: modifications during the last decades and new trends]. Arch Latinoam Nutr. 2005;55(4):367-73.
- 11de Graaf J, Stalenhoef AF. [Use of margarine fortified with phytosterols as a therapeutic food]. Ned Tijdschr Geneeskd. 2000;144(20):918-21.
- 12Nosaka N, Maki H, Suzuki Y, et al. Effects of margarine containing medium-chain triacylglycerols on body fat reduction in humans. J Atheroscler Thromb. 2003;10(5):290-8. doi:10.5551/jat.10.290
- 13Seppänen-Laakso T, Vanhanen H, Laakso I, Kohtamäki H, Viikari J. Replacement of margarine on bread by rapeseed and olive oils: effects on plasma fatty acid composition and serum cholesterol. Ann Nutr Metab. 1993;37(4):161-74. doi:10.1159/000177765
- 14Thuluva SC, Igel M, Giesa U, Lütjohann D, Sudhop T, von Bergmann K. Ratio of lathosterol to campesterol in serum predicts the cholesterol-lowering effect of sitostanol-supplemented margarine. Int J Clin Pharmacol Ther. 2005;43(7):305-10. doi:10.5414/cpp43305
- 15Weststrate JA, Ayesh R, Bauer-Plank C, Drewitt PN. Safety evaluation of phytosterol esters. Part 4. Faecal concentrations of bile acids and neutral sterols in healthy normolipidaemic volunteers consuming a controlled diet either with or without a phytosterol ester-enriched margarine. Food Chem Toxicol. 1999;37(11):1063-71. doi:10.1016/s0278-6915(99)00102-7
- 16van het Hof KH, Tijburg LB, de Boer HS, Wiseman SA, Weststrate JA. Antioxidant fortified margarine increases the antioxidant status. Eur J Clin Nutr. 1998;52(4):292-9. doi:10.1038/sj.ejcn.1600552
- 17Tavani A, Negri E, D'Avanzo B, La Vecchia C. Margarine intake and risk of nonfatal acute myocardial infarction in Italian women. Eur J Clin Nutr. 1997;51(1):30-2. doi:10.1038/sj.ejcn.1600356
- 18Bolte G, Frye C, Hoelscher B, Meyer I, Wjst M, Heinrich J. Margarine consumption and allergy in children. Am J Respir Crit Care Med. 2001;163(1):277-9. doi:10.1164/ajrccm.163.1.2006004
- 19Guggisberg D, Burton-Pimentel KJ, Walther B, et al. Molecular effects of the consumption of margarine and butter varying in trans fat composition: a parallel human intervention study. Lipids Health Dis. 2022;21(1):74. doi:10.1186/s12944-022-01675-1
- 20Laforest L, Moulin P, Schwalm MS, et al. Use of margarine enriched in phytosterols by patients at high cardiovascular risk and treated by hypolipidemic drugs. Nutr Metab Cardiovasc Dis. 2007;17(9):657-65. doi:10.1016/j.numecd.2006.07.012
- 21Meijer GW, Weststrate JA. Interesterification of fats in margarine: effect on blood lipids, blood enzymes, and hemostasis parameters. Eur J Clin Nutr. 1997;51(8):527-34. doi:10.1038/sj.ejcn.1600437
- 22Jensen CB, Berentzen TL, Gamborg M, Sørensen TI, Heitmann BL. Does prenatal exposure to vitamin D-fortified margarine and milk alter birth weight? A societal experiment. Br J Nutr. 2014;112(5):785-93. doi:10.1017/S0007114514001330
- 23Nadeem M, Imran M, Taj I, Ajmal M, Junaid M. Omega-3 fatty acids, phenolic compounds and antioxidant characteristics of chia oil supplemented margarine. Lipids Health Dis. 2017;16(1):102. doi:10.1186/s12944-017-0490-x
- 24Zhan X, Zhang X, Zhang T, Liu W, Wu H, Wei C. Preparation and Characterization of Low-Saturated Fat Margarine Through Enzymatic Interesterification: A Study on Physicochemical Properties, Crystalline Morphology, and In Vitro Digestive Behavior. J Food Sci. 2025;90(9):e70558. doi:10.1111/1750-3841.70558