E621Flavour enhancer

Monosodium glutamate

What the research shows

Prototype

Not enough

published research on this page yet

1 health finding on this page so far · See the findings

A flavor enhancer made from glutamic acid.

It intensifies the savory umami flavor of food and balances other tastes.

Written from Open Food Facts and English Wikipedia12

  • Vegan
  • Vegetarian
  • EU permitted

What research says

Animal and lab studies only

Study type not stated

  • Concern

    Food additive health risks4

    MSG is a common food additive that studies link to high blood pressure, obesity and gut trouble.

  • Open question

    Organs and body systems5

    Scientists reviewed studies on monosodium glutamate and say more research is needed on how it affects the body.

  • Open question

    Headaches after eating6

    Scientists do not yet know whether monosodium glutamate causes headaches, and studies so far disagree.

  • Open question

    Headaches and migraines8

    Scientists do not yet know whether monosodium glutamate triggers headaches, as studies give conflicting results.

  • Concern

    Brain and liver health9

    Eating foods rich in monosodium glutamate has been linked to brain, liver, weight and blood sugar problems.

  • No harm found

    Allergy and asthma symptoms10

    Decades of research have not shown a clear link between eating monosodium glutamate and asthma, hives, or a runny nose.

  • Concern

    symptoms after eating11

    Some people get headaches, sweating, stomach pain or rashes after eating monosodium glutamate in Chinese food.

How it’s made and used

  • Everyday food consumption levels3

    Scientists worked out how much monosodium glutamate people in China eat each day from everyday foods.

  • How body processes it7

    Your body handles glutamate from monosodium glutamate the same way it handles glutamate from ordinary protein foods.

The signal at the top counts the findings in people and in animal and lab studies. A concern in studies of people outranks animal and lab studies, and “No concerns” needs at least two findings in people. Findings whose study type is not stated are shown but not counted. This page is a reference, not medical advice. It describes what regulators and published research say. Talk to a doctor or dietitian about your own diet.

Regulatory status

Checked Sep 2026

Status reflects the named register on the date checked. It is not a safety rating. A country appears here once we've found this ingredient on its official list.

How we check

Products

The 6 most-scanned of 11,346 products on Open Food Facts that list monosodium glutamate.

  • Paprika Pringles · 165 g 6 additives
  • Pringles sour cream & onion Pringles · 40 g 8 additives
  • Pringles Sour Cream Pringles · 165 g 7 additives
  • Sriracha Sauce Flying Goose Brand · 455 ml 5 additives
  • Buldak Spicy Ramen Samyang · 4.94 oz (140 g) 14 additives
  • Sriracha Flying Goose Brand · 200 ml 5 additives

References

  1. 1Monosodium glutamate: ingredient taxonomy entry. Open Food Facts.
  2. 2Monosodium glutamate. Wikipedia. Accessed September 25, 2026.
  3. 3Yu H, Wang R, Zhao Y, et al. Monosodium Glutamate Intake and Risk Assessment in China Nationwide, and a Comparative Analysis Worldwide. Nutrients. 2023;15(11). doi:10.3390/nu15112444
  4. 4Chakraborty SP. Patho-physiological and toxicological aspects of monosodium glutamate. Toxicol Mech Methods. 2019;29(6):389-396. doi:10.1080/15376516.2018.1528649
  5. 5Yachmin A, Yeroshenko G, Shevchenko K, Perederii N, Ryabushko O. MONOSODIUM GLUTAMATE (E621) AND ITS EFFECT ON THE GASTROINTESTINAL ORGANS (REVIEW). Georgian Med News. 2021:147-151.
  6. 6Obayashi Y, Nagamura Y. Does monosodium glutamate really cause headache? : a systematic review of human studies. J Headache Pain. 2016;17:54. doi:10.1186/s10194-016-0639-4
  7. 7Henry-Unaeze HN. Update on food safety of monosodium l-glutamate (MSG). Pathophysiology. 2017;24(4):243-249. doi:10.1016/j.pathophys.2017.08.001
  8. 8Ahdoot E, Cohen F. Unraveling the MSG-Headache Controversy: an Updated Literature Review. Curr Pain Headache Rep. 2024;28(3):119-124. doi:10.1007/s11916-023-01198-z
  9. 9Hajihasani MM, Soheili V, Zirak MR, Sahebkar A, Shakeri A. Natural products as safeguards against monosodium glutamate-induced toxicity. Iran J Basic Med Sci. 2020;23(4):416-430. doi:10.22038/IJBMS.2020.43060.10123
  10. 10Williams AN, Woessner KM. Monosodium glutamate 'allergy': menace or myth? Clin Exp Allergy. 2009;39(5):640-6. doi:10.1111/j.1365-2222.2009.03221.x
  11. 11Shastri M, Raval DM, Rathod VM. Monosodium Glutamate (MSG) Symptom Complex (Chinese Restaurant Syndrome): Nightmare of Chinese Food Lovers! J Assoc Physicians India. 2023;71(6):11-12. doi:10.5005/japi-11001-0264
  12. 12Vorhees CV. A Test of Dietary Monosodium Glutamate Developmental Neurotoxicity in Rats: A Reappraisal. Ann Nutr Metab. 2018;73 Suppl 5:36-42. doi:10.1159/000494781