E621Flavour enhancer
Monosodium glutamate
What the research shows
PrototypeNot enough
published research on this page yet
1 health finding on this page so far · See the findings
What research says
Animal and lab studies only
-
No harm found
Brain development in young rats12
In animal studies, young rats fed monosodium glutamate showed no clear signs of harm to brain development.
Study type not stated
-
Concern
Food additive health risks4
MSG is a common food additive that studies link to high blood pressure, obesity and gut trouble.
-
Open question
Organs and body systems5
Scientists reviewed studies on monosodium glutamate and say more research is needed on how it affects the body.
-
Open question
Headaches after eating6
Scientists do not yet know whether monosodium glutamate causes headaches, and studies so far disagree.
-
Open question
Headaches and migraines8
Scientists do not yet know whether monosodium glutamate triggers headaches, as studies give conflicting results.
-
Concern
Brain and liver health9
Eating foods rich in monosodium glutamate has been linked to brain, liver, weight and blood sugar problems.
-
No harm found
Allergy and asthma symptoms10
Decades of research have not shown a clear link between eating monosodium glutamate and asthma, hives, or a runny nose.
-
Concern
symptoms after eating11
Some people get headaches, sweating, stomach pain or rashes after eating monosodium glutamate in Chinese food.
How it’s made and used
-
Everyday food consumption levels3
Scientists worked out how much monosodium glutamate people in China eat each day from everyday foods.
-
How body processes it7
Your body handles glutamate from monosodium glutamate the same way it handles glutamate from ordinary protein foods.
The signal at the top counts the findings in people and in animal and lab studies. A concern in studies of people outranks animal and lab studies, and “No concerns” needs at least two findings in people. Findings whose study type is not stated are shown but not counted. This page is a reference, not medical advice. It describes what regulators and published research say. Talk to a doctor or dietitian about your own diet.
Regulatory status
Checked Sep 2026-
European Union Permitted EUR-Lex Reg. (EC) 1333/2008
-
United Kingdom Permitted FSA retained EU law
Status reflects the named register on the date checked. It is not a safety rating. A country appears here once we've found this ingredient on its official list.
How we checkProducts
The 6 most-scanned of 11,346 products on Open Food Facts that list monosodium glutamate.
- Paprika Pringles · 165 g 6 additives
- Pringles sour cream & onion Pringles · 40 g 8 additives
- Pringles Sour Cream Pringles · 165 g 7 additives
- Sriracha Sauce Flying Goose Brand · 455 ml 5 additives
- Buldak Spicy Ramen Samyang · 4.94 oz (140 g) 14 additives
- Sriracha Flying Goose Brand · 200 ml 5 additives
References
- 1Monosodium glutamate: ingredient taxonomy entry. Open Food Facts.
- 2Monosodium glutamate. Wikipedia. Accessed September 25, 2026.
- 3Yu H, Wang R, Zhao Y, et al. Monosodium Glutamate Intake and Risk Assessment in China Nationwide, and a Comparative Analysis Worldwide. Nutrients. 2023;15(11). doi:10.3390/nu15112444
- 4Chakraborty SP. Patho-physiological and toxicological aspects of monosodium glutamate. Toxicol Mech Methods. 2019;29(6):389-396. doi:10.1080/15376516.2018.1528649
- 5Yachmin A, Yeroshenko G, Shevchenko K, Perederii N, Ryabushko O. MONOSODIUM GLUTAMATE (E621) AND ITS EFFECT ON THE GASTROINTESTINAL ORGANS (REVIEW). Georgian Med News. 2021:147-151.
- 6Obayashi Y, Nagamura Y. Does monosodium glutamate really cause headache? : a systematic review of human studies. J Headache Pain. 2016;17:54. doi:10.1186/s10194-016-0639-4
- 7Henry-Unaeze HN. Update on food safety of monosodium l-glutamate (MSG). Pathophysiology. 2017;24(4):243-249. doi:10.1016/j.pathophys.2017.08.001
- 8Ahdoot E, Cohen F. Unraveling the MSG-Headache Controversy: an Updated Literature Review. Curr Pain Headache Rep. 2024;28(3):119-124. doi:10.1007/s11916-023-01198-z
- 9Hajihasani MM, Soheili V, Zirak MR, Sahebkar A, Shakeri A. Natural products as safeguards against monosodium glutamate-induced toxicity. Iran J Basic Med Sci. 2020;23(4):416-430. doi:10.22038/IJBMS.2020.43060.10123
- 10Williams AN, Woessner KM. Monosodium glutamate 'allergy': menace or myth? Clin Exp Allergy. 2009;39(5):640-6. doi:10.1111/j.1365-2222.2009.03221.x
- 11Shastri M, Raval DM, Rathod VM. Monosodium Glutamate (MSG) Symptom Complex (Chinese Restaurant Syndrome): Nightmare of Chinese Food Lovers! J Assoc Physicians India. 2023;71(6):11-12. doi:10.5005/japi-11001-0264
- 12Vorhees CV. A Test of Dietary Monosodium Glutamate Developmental Neurotoxicity in Rats: A Reappraisal. Ann Nutr Metab. 2018;73 Suppl 5:36-42. doi:10.1159/000494781