E490
Propylene glycol
What the research shows
PrototypeNot enough
published research on this page yet
1 health finding on this page so far · See the findings
What research says
Studies in people
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Concern
Harm from eating too much2
A woman who ate large amounts of corn starch mixed with baking soda built up propylene glycol and became very ill.
Study type not stated
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Open question
Daily intake from drinks3
Propylene glycol in drinks stays below the safe daily amount, even for children who drink a lot.
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Concern
Red blood cell health5
Propylene glycol can build up in the blood and change red blood cells.
How it’s made and used
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How much we eat4
Propylene glycol was found in most Korean foods tested, with bread adding the most to daily intake.
The signal at the top counts the findings in people and in animal and lab studies. A concern in studies of people outranks animal and lab studies, and “No concerns” needs at least two findings in people. Findings whose study type is not stated are shown but not counted. This page is a reference, not medical advice. It describes what regulators and published research say. Talk to a doctor or dietitian about your own diet.
Regulatory status
Checked Sep 2026-
United States Permitted FDA 21 CFR 184.1666
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Canada Permitted Health Canada · Anticaking Agents
Status reflects the named register on the date checked. It is not a safety rating. A country appears here once we've found this ingredient on its official list.
How we checkProducts
The 6 most-scanned of 3,229 products on Open Food Facts that list propylene glycol.
- Esența Vanilie Dr.oetker · 38 ml e 3 additives
- vanilla extract Asda · 60 ml 2 additives
- Buche des fetes 14 additives
- Sweetened Coconut Flakes Great Value · 7 oz 2 additives
- cvs cleansing wipes 8 additives
- Mio Sport Berry Blast 8 additives
References
- 1Propylene glycol. Wikipedia. Accessed September 25, 2026.
- 2Peterson J, Stadlen R, Radke J. Propylene glycol toxicity from compulsive corn starch ingestion. Am J Emerg Med. 2022;53:286.e1-286.e3. doi:10.1016/j.ajem.2021.09.054
- 3Tran NL, Anderson MM, Jack MM. Tiered intake assessment for propylene glycol in beverages. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2025;42(3):317-325. doi:10.1080/19440049.2025.2449820
- 4Lim HS, Hwang JY, Choi E, Lee GY, Yun SS, Kang T. Assessment of the dietary intake of propylene glycol in the Korean population. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2016;33(8):1290-8. doi:10.1080/19440049.2016.1209576
- 5Lewis AS, Boomhower SR, Marsh CM, Jack MM. Considerations for deriving a safe intake of propylene glycol. Food Chem Toxicol. 2024;186:114460. doi:10.1016/j.fct.2024.114460