Saccharin and its salts

Animal and lab studies only

• Concern

  Heart and blood vessel health²

  In animal studies, saccharin made heart artery plaques worse in mice fed a fatty diet.

How it’s made and used

• Bitter aftertaste of sweeteners¹

  Some cooling compounds block the bitter taste receptors that give saccharin its unpleasant aftertaste.

The signal at the top counts the findings in people and in animal and lab studies. A concern in studies of people outranks animal and lab studies, and “No concerns” needs at least two findings in people. Findings whose study type is not stated are shown but not counted. This page is a reference, not medical advice. It describes what regulators and published research say. Talk to a doctor or dietitian about your own diet.