E222Antioxidant · Preservative

Sodium bisulphite

What the research shows

Concerning

in animal and lab studies only

Used in food as an antioxidant or preservative.

  • Vegan
  • Vegetarian
  • EU permitted

What research says

Animal and lab studies only

  • Concern

    Gut inflammation1

    In lab and animal studies, sodium bisulphite raised gut inflammation, and vitamin B6 seemed to reduce it.

The signal at the top counts the findings in people and in animal and lab studies. A concern in studies of people outranks animal and lab studies, and “No concerns” needs at least one finding in people. When most findings in people point one way, the page leans that way (“Mostly”), and every finding is still shown. Findings whose study type is not stated are shown but not counted. This page is a reference, not medical advice. It describes what regulators and published research say. Talk to a doctor or dietitian about your own diet.

What expert reviews concluded

Expert panels that weigh all the research. Shown for context: the signal at the top does not count them. IARC rates whether something can cause cancer at all, not how likely it is at the amounts in food.

Regulatory status

Checked Sep 2026

Status reflects the named register on the date checked. It is not a safety rating.

How we check

Products

The 6 most-scanned of 1,764 products on Open Food Facts that list sodium bisulphite.

  • Sriracha Hot Chili Sauce Huy Fong Foods · 482 g 4 additives
  • SRIRACHA HOT CHILI SAUCE Huy Fong Foods · 793 g 2 additives
  • Blackcurrant Squash Ribena · 850 ml 7 additives
  • Ribena Hitachino · 1.5 L 6 additives
  • Buttery Homestyle Mashed Potatoes Idahoan · 1.36 kg 4 additives
  • Hashbrown Potatoes Idaho Spuds · 119gx1 1 additive

References

  1. 1Wu W, Fu G, Xuan R, et al. Food additive sodium bisulfite induces intracellular imbalance of biothiols levels in NCM460 colonic cells to trigger intestinal inflammation in mice. Toxicol Lett. 2022;359:73-83. doi:10.1016/j.toxlet.2022.01.019