E220Antioxidant · Preservative
Sulphur dioxide
What the research shows
Concerning
in studies of people*
*Allergies present
A colorless gas with a pungent smell.1
- Vegan
- Vegetarian
- EU permitted
What research says
Studies in people
-
Concern
Gut and oral bacteria2
Eating sulphur dioxide has been linked to upset gut and mouth bacteria, plus allergic reactions in some people.
-
Open question
Children's intake risk3
In some Chinese children, eating sulphur dioxide in food added up to more than the safe daily amount.
-
Concern
Asthma attacks from food6
Some asthmatics react to sulphur dioxide in food with breathing attacks, though tests often give false alarms.
-
Concern
Asthma in sensitive people8
Some people with asthma say sulphur dioxide in soft drinks makes their asthma worse.
-
Concern
Asthma flare-ups from drinks9
Some people with asthma reacted to sulphur dioxide in orange drinks, with breathing getting worse after drinking them.
-
Open question
Daily intake limits10
Adults who always pick preservative-containing foods may take in more sulphites than the recommended daily limit, mostly from wine.
Animal and lab studies only
-
Concern
Male fertility11
In animal studies, sulphur dioxide in drinks made from dried apricot leather raised sperm problems and lowered testosterone.
-
Concern
Long-term health effects12
In animal studies, low levels of sulphur dioxide seemed relatively harmless, but the authors say those studies may mislead.
Found in some samples or products
These come from where it was grown, how it was processed or cooked, or what it was made into. They are not about the ingredient itself, so the signal does not count them.
-
Sensitivity to food additives5
Some people react badly to sulphites left in food, so scientists measure them to check levels.
Allergies and intolerances
These are about people with an allergy, an intolerance or coeliac disease. The signal is about the ingredient itself, and these are about the person eating it, so the signal does not count them.
-
Asthma flare-ups7
Sulfur dioxide and sulfites used in foods may set off sudden asthma attacks in some people.
How it’s made and used
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Children's health risk4
In some dried fruits and vegetables, sulphur dioxide levels were high enough that children could take in too much.
The signal at the top counts the findings in people and in animal and lab studies. A concern in studies of people outranks animal and lab studies, and “No concerns” needs at least one finding in people. When most findings in people point one way, the page leans that way (“Mostly”), and every finding is still shown. Findings whose study type is not stated are shown but not counted. This page is a reference, not medical advice. It describes what regulators and published research say. Talk to a doctor or dietitian about your own diet.
What expert reviews concluded
Expert panels that weigh all the research. Shown for context: the signal at the top does not count them. IARC rates whether something can cause cancer at all, not how likely it is at the amounts in food.
-
UN and WHO food additive experts (JECFA), 1998
Acceptable daily intake: up to 0.7 mg per kg of body weight.
-
WHO cancer agency (IARC), 1991
Not enough evidence to say whether it causes cancer in people (Group 3).
Regulatory status
Checked Sep 2026-
United States Permitted FDA 21 CFR 182.3862
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European Union Permitted EUR-Lex Reg. (EC) 1333/2008
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United Kingdom Permitted FSA retained EU law
Status reflects the named register on the date checked. It is not a safety rating. A country appears here once we've found this ingredient on its official list.
How we checkProducts
The 6 most-scanned of 2,121 products on Open Food Facts that list sulphur dioxide.
- Big Mac McDonald's · 232 g 18 additives
- Pesto Sun-Dried Tomato Saclà · 190 g 2 additives
- Probiotic Apricots Nature's Garden 1 additive
- Fiery Red Chilli Pesto Sacla' · 190 g 2 additives
- Fruit and nut muesli Waitrose · 1 kg 0 additives
- PLJ Lemon Rayner's · 500 ml 1 additive
References
- 1Sulfur dioxide. Wikipedia. Accessed September 26, 2026. CC BY-SA 4.0.
- 2D'Amore T, Di Taranto A, Berardi G, et al. Sulfites in meat: Occurrence, activity, toxicity, regulation, and detection. A comprehensive review. Compr Rev Food Sci Food Saf. 2020;19(5):2701-2720. doi:10.1111/1541-4337.12607
- 3Zhang JB, Zhang H, Wang HL, et al. Risk analysis of sulfites used as food additives in China. Biomed Environ Sci. 2014;27(2):147-54. doi:10.3967/bes2014.032
- 4Lou T, Huang W, Wu X, et al. Monitoring, exposure and risk assessment of sulfur dioxide residues in fresh or dried fruits and vegetables in China. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2017;34(6):918-927. doi:10.1080/19440049.2017.1313458
- 5Fazio T, Warner CR. A review of sulphites in foods: analytical methodology and reported findings. Food Addit Contam. 1990;7(4):433-54. doi:10.1080/02652039009373907
- 6Giffon E, Vervloet D, Charpin J. [Suspicion on sulfites]. Rev Mal Respir. 1989;6(4):303-10.
- 7Mathison DA, Stevenson DD, Simon RA. Precipitating factors in asthma. Aspirin, sulfites, and other drugs and chemicals. Chest. 1985;87(1 Suppl):50S-54S. doi:10.1378/chest.87.1.50s
- 8Freedman BJ. Sulphur dioxide in foods and beverages: its use as a preservative and its effect on asthma. Br J Dis Chest. 1980;74(2):128-34. doi:10.1016/0007-0971(80)90023-6
- 9Freedman BJ. Asthma induced by sulphur dioxide, benzoate and tartrazine contained in orange drinks. Clin Allergy. 1977;7(5):407-15. doi:10.1111/j.1365-2222.1977.tb01471.x
- 10Mischek D, Krapfenbauer-Cermak C. Exposure assessment of food preservatives (sulphites, benzoic and sorbic acid) in Austria. Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2012;29(3):371-82. doi:10.1080/19440049.2011.643415
- 11Zaki EI, El-Mahdy AR, El-Gamal HM, El-Seedy AS. Cytogenetic and testicular histological alterations induced by sulphur dioxide in dried apricot leather. Cell Mol Biol (Noisy-le-grand). 2021;67(2):66-75. doi:10.14715/cmb/2021.67.2.10
- 12Hickey RJ, Clelland RC, Bowers EJ, Boyce DE. Health effects of atmospheric sulfur dioxide and dietary sulfites. The fallacy of typology. Arch Environ Health. 1976;31(2):108-12. doi:10.1080/00039896.1976.10667201