E161hColour
Zeaxanthin
What the research shows
No concerns
none of the findings here link it to harm
Used in food as a colour.
- Vegan
- Vegetarian
What research says
Studies in people
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Benefit
Eye health1
Zeaxanthin is a plant pigment that builds up in the eye and may help slow eye diseases like macular degeneration.
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Open question
Vision loss in older adults2
In people at risk of vision loss, taking zeaxanthin with lutein did not clearly slow the disease.
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No harm found
Lung cancer risk3
In people, zeaxanthin did not raise lung cancer risk, unlike beta carotene, which nearly doubled it.
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Benefit
Heart artery health4
In people, zeaxanthin with lutein and meso-zeaxanthin lowered blood markers of inflammation and oxidized fats linked to artery plaque.
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Benefit
Dry eye symptoms5
People taking zeaxanthin with lutein and elderberry for 20 days reported less dry eye discomfort.
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Benefit
Eye-hand coordination6
In people, a mix with zeaxanthin, lutein and astaxanthin helped eye-hand coordination after screen work.
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Benefit
Children's eye and brain health7
In children, zeaxanthin gummies with lutein improved eye strain, focus and memory over six months.
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Benefit
Eye pigment in the retina8
In people, taking zeaxanthin with lutein raised the eye's protective pigment, measured in the retina.
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Benefit
Eye health and vision loss9
Eating more zeaxanthin from foods like leafy greens and eggs may help protect against a common cause of blindness.
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Open question
Skin wrinkles and hydration10
In people, a zeaxanthin supplement plus a skin cream improved hydration and reduced facial wrinkles compared with placebo.
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Open question
Age-related macular degeneration13
Eating zeaxanthin didn't clearly lower the risk of early AMD, though a possible link to the worse form needs more study.
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No harm found
Children's eyesight15
Eating zeaxanthin during pregnancy showed no clear link to children's eyesight at age 11 or 12.
Animal and lab studies only
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Benefit
Body fat and obesity22
In animal studies, zeaxanthin reduced body fat and improved blood fat levels in mice fed a high-fat diet.
Study type not stated
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Benefit
Eye health and vision16
Zeaxanthin is one of the pigments that collects in the eye's macula, and it may help protect against vision loss.
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Benefit
Eye health and vision18
Zeaxanthin is thought to help protect eyes from light damage, but scientists do not yet know all the answers.
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Benefit
Infant eye and brain development19
Zeaxanthin may help a baby's eyes and brain grow, but scientists do not yet know for sure.
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Benefit
Eye and skin protection20
Zeaxanthin is found in the eye and skin, where it may help protect against light damage.
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Benefit
Eye and brain health21
Zeaxanthin is taken up into eye tissue and may help protect against blue light damage.
How it’s made and used
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Eye health and ageing11
In 8,525 US survey participants, zeaxanthin intake was lower than lutein, and the gap widened with age and in women.
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Nutrient absorption from food12
Zeaxanthin from wolfberry berries mixed into hot skimmed milk was absorbed about three times better than from hot water.
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How much the body absorbs14
In people, zeaxanthin from one supplement reached the blood at higher levels than another supplement.
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Plant pigment levels17
In plants, zeaxanthin is scarce in leafy vegetables because it quickly converts to violaxanthin.
The signal at the top counts the findings in people and in animal and lab studies. A concern in studies of people outranks animal and lab studies, and “No concerns” needs at least one finding in people. When most findings in people point one way, the page leans that way (“Mostly”), and every finding is still shown. Findings whose study type is not stated are shown but not counted. This page is a reference, not medical advice. It describes what regulators and published research say. Talk to a doctor or dietitian about your own diet.
Products
The 6 most-scanned of 56 products on Open Food Facts that list zeaxanthin.
- Huel Black Edition Powder - Chocolate Huel · 1 pouch 5 additives
- Black edition powder Huel · 1 pouch 5 additives
- Huel Black Edition Powder - Vanilla Huel · 1 pouch 5 additives
- Huel Instant Meals - Mexican Chilli Huel · 1 pouch 3 additives
- Huel Instant Meals - Korma Huel · 1 pouch 4 additives
- Huel Instant Meals - Sweet & Sour Huel · 1 pouch 6 additives
References
- 1Mrowicka M, Mrowicki J, Kucharska E, Majsterek I. Lutein and Zeaxanthin and Their Roles in Age-Related Macular Degeneration-Neurodegenerative Disease. Nutrients. 2022;14(4). doi:10.3390/nu14040827
- 2Age-Related Eye Disease Study 2 Research Group. Lutein + zeaxanthin and omega-3 fatty acids for age-related macular degeneration: the Age-Related Eye Disease Study 2 (AREDS2) randomized clinical trial. JAMA. 2013;309(19):2005-15. doi:10.1001/jama.2013.4997
- 3Chew EY, Clemons TE, Agrón E, et al. Long-term Outcomes of Adding Lutein/Zeaxanthin and ω-3 Fatty Acids to the AREDS Supplements on Age-Related Macular Degeneration Progression: AREDS2 Report 28. JAMA Ophthalmol. 2022;140(7):692-698. doi:10.1001/jamaophthalmol.2022.1640
- 4Stringham NT, Green M, Roche W, Prado-Cabrero A, Mulcahy R, Nolan J. Lutein, zeaxanthin, and meso-zeaxanthin supplementation attenuates inflammatory cytokines and markers of oxidative cardiovascular processes in humans. Nutr Metab Cardiovasc Dis. 2024;34(8):1976-1983. doi:10.1016/j.numecd.2024.05.009
- 5Goh KM, Tan ESS, Lim CSY, et al. Effect of Dietary Supplementation with Lutein, Zeaxanthin, and Elderberries on Dry Eye Disease (DED) and Immunity: A Randomized Controlled Trial. Nutrients. 2024;16(24). doi:10.3390/nu16244366
- 6Yoshida K, Sakai O, Honda T, et al. Effects of Astaxanthin, Lutein, and Zeaxanthin on Eye-Hand Coordination and Smooth-Pursuit Eye Movement after Visual Display Terminal Operation in Healthy Subjects: A Randomized, Double-Blind Placebo-Controlled Intergroup Trial. Nutrients. 2023;15(6). doi:10.3390/nu15061459
- 7Parekh R, Hammond BR Jr, Chandradhara D. Lutein and Zeaxanthin Supplementation Improves Dynamic Visual and Cognitive Performance in Children: A Randomized, Double-Blind, Parallel, Placebo-Controlled Study. Adv Ther. 2024;41(4):1496-1511. doi:10.1007/s12325-024-02785-1
- 8Ma L, Liu R, Du JH, Liu T, Wu SS, Liu XH. Lutein, Zeaxanthin and Meso-zeaxanthin Supplementation Associated with Macular Pigment Optical Density. Nutrients. 2016;8(7). doi:10.3390/nu8070426
- 9Eisenhauer B, Natoli S, Liew G, Flood VM. Lutein and Zeaxanthin-Food Sources, Bioavailability and Dietary Variety in Age-Related Macular Degeneration Protection. Nutrients. 2017;9(2). doi:10.3390/nu9020120
- 10Schwartz S, Frank E, Gierhart D, Simpson P, Frumento R. Zeaxanthin-based dietary supplement and topical serum improve hydration and reduce wrinkle count in female subjects. J Cosmet Dermatol. 2016;15(4):e13-e20. doi:10.1111/jocd.12226
- 11Johnson EJ, Maras JE, Rasmussen HM, Tucker KL. Intake of lutein and zeaxanthin differ with age, sex, and ethnicity. J Am Diet Assoc. 2010;110(9):1357-62. doi:10.1016/j.jada.2010.06.009
- 12Benzie IF, Chung WY, Wang J, Richelle M, Bucheli P. Enhanced bioavailability of zeaxanthin in a milk-based formulation of wolfberry (Gou Qi Zi; Fructus barbarum L.). Br J Nutr. 2006;96(1):154-60. doi:10.1079/bjn20061796
- 13Cho E, Hankinson SE, Rosner B, Willett WC, Colditz GA. Prospective study of lutein/zeaxanthin intake and risk of age-related macular degeneration. Am J Clin Nutr. 2008;87(6):1837-43. doi:10.1093/ajcn/87.6.1837
- 14Choe BS, C A, Mk P, Kim J, Baek KS, Park YK. Enhanced Oral Bioavailability of Lutein and Zeaxanthin via a Self-Emulsifying Delivery System: A Randomized, Double-Blind Cross-Over Study. J Med Food. 2025;28(8):824-832. doi:10.1089/jmf.2025.k.0060
- 15Anderson MJ, Romaguera D, Saint-Amour D, et al. Lutein and Zeaxanthin Intake during Pregnancy and Visual Function in Offspring at 11-12 Years of Age. Nutrients. 2022;14(4). doi:10.3390/nu14040872
- 16Bernstein PS, Li B, Vachali PP, et al. Lutein, zeaxanthin, and meso-zeaxanthin: The basic and clinical science underlying carotenoid-based nutritional interventions against ocular disease. Prog Retin Eye Res. 2016;50:34-66. doi:10.1016/j.preteyeres.2015.10.003
- 17Demmig-Adams B, López-Pozo M, Stewart JJ, Adams WW 3rd. Zeaxanthin and Lutein: Photoprotectors, Anti-Inflammatories, and Brain Food. Molecules. 2020;25(16). doi:10.3390/molecules25163607
- 18Jia YP, Sun L, Yu HS, et al. The Pharmacological Effects of Lutein and Zeaxanthin on Visual Disorders and Cognition Diseases. Molecules. 2017;22(4). doi:10.3390/molecules22040610
- 19Giordano E, Quadro L. Lutein, zeaxanthin and mammalian development: Metabolism, functions and implications for health. Arch Biochem Biophys. 2018;647:33-40. doi:10.1016/j.abb.2018.04.008
- 20Roberts RL, Green J, Lewis B. Lutein and zeaxanthin in eye and skin health. Clin Dermatol. 2009;27(2):195-201. doi:10.1016/j.clindermatol.2008.01.011
- 21Johnson EJ. Role of lutein and zeaxanthin in visual and cognitive function throughout the lifespan. Nutr Rev. 2014;72(9):605-12. doi:10.1111/nure.12133
- 22Liu M, Liu H, Xie J, et al. Anti-obesity effects of zeaxanthin on 3T3-L1 preadipocyte and high fat induced obese mice. Food Funct. 2017;8(9):3327-3338. doi:10.1039/c7fo00486a