Hydroxypropyl distarch phosphate and energy use in men
What it found
In ten healthy men, a meal made with hydroxypropyl-distarch phosphate led to higher resting energy use and fat burning than a meal with waxy maize starch.
It also led to lower blood sugar, insulin and GIP responses after eating.
What they found
Studies in people
Energy use after eating
The hydroxypropyl-distarch phosphate meal caused higher resting energy expenditure than the waxy maize starch meal.
Fat burning
Fat utilisation was higher after the hydroxypropyl-distarch phosphate meal than after the waxy maize starch meal.
Blood sugar and insulin
The hydroxypropyl-distarch phosphate meal led to significantly lower postprandial glucose and insulin responses than the waxy maize starch meal.
GIP response
The hydroxypropyl-distarch phosphate meal led to a significantly lower postprandial GIP response than the waxy maize starch meal.
Links with GIP
Postprandial resting energy expenditure and fat utilisation were negatively correlated with the postprandial GIP response, but not with glucose and insulin responses.
What the authors conclude
“In conclusion, dietary supplementation with HDP lowers postprandial GIP and increases postprandial REE and fat utilisation in healthy humans.”
Also in their conclusions
- They conclude that dietary supplementation with hydroxypropyl-distarch phosphate lowers postprandial GIP and increases postprandial resting energy expenditure and fat utilisation in healthy humans.
- They say an HDP-rich diet may therefore have beneficial implications in weight management.
- They state that further studies are required to confirm the efficacy in overweight or obese subjects, and to determine the precise mechanisms.
How it was done
The authors wanted to find out how hydroxypropyl-distarch phosphate supplementation affects energy metabolism and glucose-dependent insulinotropic polypeptide after a meal in people.
Ten healthy men with a mean BMI of 23·6 (SEM 1·3) kg/m(2), age 35·2 (SEM 1·9) years and body weight 71·1 (SEM 4·0) kg took part in a randomised, cross-over study. They ate two test meals of 1673·6 kJ, one with waxy maize starch and one with hydroxypropyl-distarch phosphate from waxy maize starch. Resting energy expenditure and blood markers were measured before the meal and for up to 180 minutes after.
What it can’t tell you
- We summarised it from the abstract only.
- This was a small study in ten healthy men, so the results may not apply to women, other age groups, or people with different health conditions.
- The study only looked at one meal and measured effects for up to 180 minutes, so it cannot show what happens with long-term use.
- The authors themselves say further studies are needed to confirm the findings in overweight or obese people.
Who paid
- Authors work at
- Biological Science Laboratories, Japan
The paper
- Title
- Dietary supplementation with hydroxypropyl-distarch phosphate from waxy maize starch increases resting energy expenditure by lowering the postprandial glucose-dependent insulinotropic polypeptide response in human subjects
- Type
- Randomised controlled trial
- Evidence
- Studies in people
- Summarised from
- Abstract only
- Cite
- Shimotoyodome A, Suzuki J, Kameo Y, Hase T (2011). Dietary supplementation with hydroxypropyl-distarch phosphate from waxy maize starch increases resting energy expenditure by lowering the postprandial glucose-dependent insulinotropic polypeptide response in human subjects. The British journal of nutrition. doi:10.1017/S0007114510005854PubMed 21338535DOI
Summary written 26 Sep 2026. Check it against the paper before it changes what you eat. How we summarise papers · Report an error