Anthocyanins and platelet activity in healthy people
What it found
In 26 healthy people, taking 320 mg of anthocyanins daily for 28 days reduced ADP-stimulated platelet aggregation and lowered fibrinogen levels.
The authors say this might lower thrombotic risk.
What they found
Studies in people
Platelet aggregation
ADP-stimulated platelet aggregation fell significantly after anthocyanin supplementation. Platelet aggregation was also tested with collagen and arachidonic acid.
Platelet activation marker
Flow cytometry showed a significant effect of anthocyanins on P-selectin expression, measured as CD62p on the platelet surface.
Blood clotting factor
Coagulation analysis showed a significant drop in fibrinogen level in the blood.
Blood cell measures
Mean platelet volume, mean cell hemoglobin and mean cell hemoglobin concentration all fell significantly.
What the authors conclude
“These results suggest that AC has a positive impact on attenuating platelet activity, which might minimize thrombotic risk.”
Also in their conclusions
- They say the study showed inhibition of platelet activity, platelet aggregation and mean platelet volume.
- They suggest that anthocyanins have a positive impact on attenuating platelet activity, which might minimize thrombotic risk.
How it was done
Platelet hyperactivity plays a key role in starting vascular thrombosis and cardiovascular disease. The authors wanted to see whether anthocyanins affect platelet aggregation, platelet activation and lipid profile.
26 healthy people aged 25 to 75 took 320 mg of anthocyanins daily as Medox capsules for 28 days. Fasting blood samples were taken before and after to measure platelet activation markers, platelet aggregation, full blood count, coagulation and biochemistry.
What it can’t tell you
- We summarised it from the abstract only.
- This was a small study of 26 healthy people, so the results may not apply to people with cardiovascular disease or other groups.
- The study lasted 28 days, so it cannot show what happens over longer periods.
- It did not compare anthocyanins with a placebo, so it cannot prove the effects were caused by anthocyanins alone.
The paper
- Title
- Anthocyanin Supplementation Alleviates Antithrombotic Risk by Inhibiting Platelet Activity in Humans
- Type
- Study
- Evidence
- Studies in people
- Summarised from
- Abstract only
- Cite
- Gaiz A, Kundur AR, Nikbakht E, et al (2022). Anthocyanin Supplementation Alleviates Antithrombotic Risk by Inhibiting Platelet Activity in Humans. Alternative therapies in health and medicine.PubMed 33789251
Summary written 26 Sep 2026. Check it against the paper before it changes what you eat. How we summarise papers · Report an error