Curcumin with piperine and effects on human health
What it found
Taking curcumin together with piperine was linked to better blood sugar, cholesterol and antioxidant measures in people with diabetes, and to less inflammation in people with obesity or metabolic syndrome.
It was also linked to less oxidative stress and depression in people under chronic stress or with neurological disorders, and to improvements in chronic respiratory diseases, asthma and COVID-19.
What they found
Studies in people
Blood sugar and lipids
In people with diabetes, curcumin-piperine co-supplementation improved glycemic indices and lipid profile.
Antioxidant status in diabetes
In people with diabetes, the combination improved antioxidant status.
Inflammation in obesity
In people with obesity and metabolic syndrome, it improved the inflammatory status caused by these conditions.
Stress and neurological disorders
In people with chronic stress and neurological disorders, it reduced oxidative stress and depression.
Respiratory conditions
It improved chronic respiratory diseases, asthma and COVID-19.
What the authors conclude
“Further high-quality clinical trial studies are needed to firmly establish the clinical efficacy of the curcumin-piperine supplement.”
Also in their conclusions
- They say the findings show beneficial effects of curcumin-piperine on glycemic indices, lipid profile and antioxidant status in diabetes, on inflammatory status in obesity and metabolic syndrome, on oxidative stress and depression in chronic stress and neurological disorders, and on chronic respiratory diseases, asthma and COVID-19.
- They advise that further high-quality clinical trial studies are needed to firmly establish the clinical efficacy of the curcumin-piperine supplement.
How it was done
Curcumin comes from the rhizomes of Curcuma longa L. and is known for its anti-inflammatory and anti-oxidant activities. Its usefulness is limited because only a small amount is taken up when swallowed, and taking it with piperine may improve this.
What it can’t tell you
- We summarised it from the abstract only.
- This review pulls together other studies, so it cannot show that curcumin-piperine itself causes these changes.
- The authors say more high-quality clinical trials are needed before the supplement's clinical efficacy is firmly established.
Who paid
- Authors work at
- Isfahan University of Medical Sciences, Iran; University of Hull, United Kingdom; Mashhad University of Medical Sciences, Iran
The paper
- Title
- Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies
- Type
- ReviewThe authors read earlier studies and describe what they found. It isn’t a new study.
- Evidence
- Studies in people
- Summarised from
- Abstract only
- Cite
- Heidari H, Bagherniya M, Majeed M, Sathyapalan T, Jamialahmadi T, Sahebkar A (2023). Curcumin-piperine co-supplementation and human health: A comprehensive review of preclinical and clinical studies. Phytotherapy research. doi:10.1002/ptr.7737PubMed 36720711DOI
Summary written 26 Sep 2026. Check it against the paper before it changes what you eat. How we summarise papers · Report an error