Flaxseed oil and apolipoprotein E genotypes in type 2 diabetes
What it found
In people with type 2 diabetes, flaxseed oil lowered platelet clumping compared with a placebo oil, but apolipoprotein E genotype did not change how anyone responded.
The authors say genotype played no role in the responses they measured.
What they found
Studies in people
Platelet clumping
Platelet aggregability decreased with flaxseed oil compared with the placebo oil.
LDL oxidation
There appeared to be some potential for flaxseed oil to decrease LDL conjugated dienes.
Apolipoprotein E genotype
No apolipoprotein E genotype affected how any of the seven measures responded to flaxseed oil.
What the authors conclude
“Identified apolipoprotein E genotypes played no role in the responsiveness of any member of the cluster of seven to FOS in this study.”
Also in their conclusions
- They conclude that identified apolipoprotein E genotypes played no role in the responsiveness of any member of the cluster of seven to flaxseed oil in this study.
How it was done
The authors wanted to see whether apolipoprotein E genotype would affect how people with type 2 diabetes respond to a flaxseed oil supplement across seven measures tied to their condition.
Thirty-two patients with well-controlled type 2 diabetes took part in a double-blind, placebo-controlled study with three visits. They received either flaxseed oil or safflower oil, and the seven measures were checked at each visit.
What it can’t tell you
- We summarised it from the abstract only.
- The study was small and looked only at people with well-controlled type 2 diabetes, so the results may not apply to others.
- It cannot show whether flaxseed oil would affect these measures over a longer time or at different doses.
Who paid
- Authors work at
- Cape Breton University, Canada
The paper
- Title
- Thus far there are no statistically significant differences between various apolipoprotein E genotypes in the cluster of seven responsiveness to a flaxseed oil supplement in persons with type 2 diabetes
- Type
- Randomised controlled trial
- Evidence
- Studies in people
- Summarised from
- Abstract only
- Cite
- Barre DE, Mizier-Barre KA, Griscti O (2025). Thus far there are no statistically significant differences between various apolipoprotein E genotypes in the cluster of seven responsiveness to a flaxseed oil supplement in persons with type 2 diabetes. Endocrine regulations. doi:10.2478/enr-2025-0016PubMed 40958692DOI
Summary written 26 Sep 2026. Check it against the paper before it changes what you eat. How we summarise papers · Report an error