Pectin prebiotics in peach allergic patients
What it found
In people with peach allergy, two pectins increased allergen tolerance in more than 50% of patients and changed gut bacteria and immune markers.
The authors say pectin treatment is a promising option for LTP allergy.
What they found
Studies in people
Allergen tolerance
Both pectins led to a significant clinical increase in allergen tolerance in more than 50% of patients.
Immune response
Both pectin groups showed a drop in various inflammatory cytokines compared to placebo.
Gut bacteria changes
Citrus pectin increased Bacteroides_H and Roseburia intestinalis. Apple pectin increased Bifidobacterium, Succinivibrio, and Faecalibacterium prausnitzii.
Short-chain fatty acids
Both pectins reduced levels of branched short-chain fatty acids compared to placebo.
Bile acids
Pectin supplementation changed fecal levels of microbial-derived secondary bile acids.
What the authors conclude
“This study suggests that pectin treatment is a promising and safe option for LTP allergy.”
Also in their conclusions
- They suggest that pectin treatment is a promising and safe option for LTP allergy.
How it was done
There is great interest in using pectins as prebiotic treatment for food allergy.
Peach allergic patients sensitised to lipid transfer proteins were given low methoxyl citrus pectin, high methoxyl apple pectin, or a placebo. The study looked at immune response, gut bacteria, and microbial products including short-chain fatty acids and bile acids.
What it can’t tell you
- We summarised it from the abstract only.
- The study only looked at peach allergic patients sensitised to lipid transfer proteins, so the results may not apply to other allergies or other groups.
- It does not show whether these changes last beyond the study period.
Who paid
- Conflicts
- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
- Authors work at
- Hospital Regional Universitario de Málaga, Spain; CEU Universities, Spain; Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina (IBIMA Plataforma BIONAND), Spain
The paper
- Title
- Multi-omics analysis of a prebiotic intervention with pectin in lipid transfer proteins (LTPs) allergic patients
- Type
- Randomised controlled trial
- Evidence
- Studies in people
- Summarised from
- Abstract only
- Cite
- Gómez F, Pérez-Sánchez N, Macías-Camero A, et al (2025). Multi-omics analysis of a prebiotic intervention with pectin in lipid transfer proteins (LTPs) allergic patients. Carbohydrate polymers. doi:10.1016/j.carbpol.2025.124236PubMed 40973277DOI
Summary written 26 Sep 2026. Check it against the paper before it changes what you eat. How we summarise papers · Report an error