Bifidobacterium lactis

What the research shows

Mostly no concerns

most studies in people found no harm or a benefit

A bacterium found in the large intestines of humans.

It is used as a probiotic in products.1

What research says

Studies in people

  • No harm found

    Infant growth2

    Babies fed formula with Bifidobacterium lactis grew the same as babies fed formula without it.

  • Open question

    Gut transit time3

    In people, Bifidobacterium lactis was linked to faster gut transit, but scientists say evidence for health claims is still insufficient.

  • Benefit

    Gut health in preterm babies4

    In preterm babies, Bifidobacterium lactis raised good gut bacteria, but studies were too small to prove it prevents gut disease.

  • Benefit

    Immune system support5

    Bifidobacterium lactis HN019 may help the immune system, but most studies lasted only a few weeks.

  • Benefit

    Constipation in women6

    Women with constipation who drank milk with Bifidobacterium lactis went to the toilet more often and more easily.

  • No harm found

    Constipation relief7

    In people with constipation, Bifidobacterium lactis HN019 did not increase complete spontaneous bowel movements more than placebo.

  • Benefit

    Gas and bloating8

    In people with gut-brain disorders, Bifidobacterium lactis in a fermented milk product for 28 days reduced reported flatulence and gas episodes.

  • Benefit

    Mouth bacteria and tooth decay9

    Students who ate yogurt with Bifidobacterium lactis had fewer decay-causing mouth bacteria in their saliva.

  • Benefit

    Inflammation and oxidative stress10

    People who took Bifidobacterium lactis HN019 in milk for 90 days had lower inflammation and oxidative stress markers.

  • Benefit

    Gut health in adults11

    In healthy adults, eating yogurt with Bifidobacterium lactis raised a gut substance and lowered mutagenicity.

  • Benefit

    Immune health in older adults12

    In older people, drinking milk with Bifidobacterium lactis for six weeks boosted some immune defences.

  • Open question

    Gut bacteria survival13

    Whether Bifidobacterium lactis stays in your gut may depend on the bacteria already living there.

  • No harm found

    Gut bacteria during antibiotics14

    In adults taking antibiotics, eating yogurt with Bifidobacterium lactis caused no more reported side effects than plain yogurt.

  • Benefit

    Seasonal hay fever symptoms15

    People with hay fever taking Bifidobacterium lactis had lower nasal symptom scores than those taking a placebo.

  • Benefit

    Infant gut immunity16

    In infants fed formula with Bifidobacterium lactis, stool IgA rose in some, and immune response after shots rose in cesarean-delivered infants.

  • Benefit

    Gut comfort in women17

    Women who drank milk with Bifidobacterium lactis daily reported better gut comfort, but the effect faded within a week of stopping.

  • Benefit

    Baby immune development18

    In mothers who took Bifidobacterium lactis, early breast milk had more TGF-beta1 and IgA, and babies' cord blood had less sCD14.

  • Benefit

    Mouth bacteria19

    In young adults, eating ice-cream with Bifidobacterium lactis daily may lower levels of mutans streptococci in saliva.

  • Concern

    Gut bacteria and bowel habits20

    Bifidobacterium lactis survived digestion and showed up in stool, and higher doses made stool looser.

Animal and lab studies only

  • Benefit

    Mould toxin in food21

    Bifidobacterium lactis reduced the mutation-causing effect of aflatoxin B1, a mould toxin sometimes found in food.

  • Open question

    Gut inflammation and cancer22

    In lab studies, Bifidobacterium lactis raised Cox-1 and lowered Cox-2 in gut cells, but the authors only suggest this may matter.

The signal at the top counts the findings in people and in animal and lab studies. A concern in studies of people outranks animal and lab studies, and “No concerns” needs at least one finding in people. When most findings in people point one way, the page leans that way (“Mostly”), and every finding is still shown. Findings whose study type is not stated are shown but not counted. This page is a reference, not medical advice. It describes what regulators and published research say. Talk to a doctor or dietitian about your own diet.

Products

The 6 most-scanned of 530 products on Open Food Facts that list bifidobacterium lactis.

  • Fermented Coconut Yoghurt Alternative The Coconut Collab · 350 g 1 additive
  • KEFIR YOGURT Passion Fruit Mango and Papaya Graham's · 350 g 0 additives
  • organic supergreens fruits & vegetables zena greens 4 additives
  • Activia Strawberry Yogurt Danone 1 additive
  • GREEK NONFAT YOGURT PLAIN TRADER JOE'S · 2 lb (907 g) 0 additives
  • simple ingredient skyr PLAIN siggi's 0 additives

References

  1. 1Bifidobacterium lactis: ingredient taxonomy entry. Open Food Facts.
  2. 2Szajewska H, Chmielewska A. Growth of infants fed formula supplemented with Bifidobacterium lactis Bb12 or Lactobacillus GG: a systematic review of randomized controlled trials. BMC Pediatr. 2013;13:185. doi:10.1186/1471-2431-13-185
  3. 3Meléndez-Illanes L, González-Díaz C, Chilet-Rosell E, Álvarez-Dardet C. Does the scientific evidence support the advertising claims made for products containing Lactobacillus casei and Bifidobacterium lactis? A systematic review. J Public Health (Oxf). 2016;38(3):e375-e383. doi:10.1093/pubmed/fdv151
  4. 4Szajewska H, Guandalini S, Morelli L, Van Goudoever JB, Walker A. Effect of Bifidobacterium animalis subsp lactis supplementation in preterm infants: a systematic review of randomized controlled trials. J Pediatr Gastroenterol Nutr. 2010;51(2):203-9. doi:10.1097/MPG.0b013e3181dc0d93
  5. 5Sanders ME. Summary of probiotic activities of Bifidobacterium lactis HN019. J Clin Gastroenterol. 2006;40(9):776-83. doi:10.1097/01.mcg.0000225576.73385.f0
  6. 6Yang YX, He M, Hu G, et al. Effect of a fermented milk containing Bifidobacterium lactis DN-173010 on Chinese constipated women. World J Gastroenterol. 2008;14(40):6237-43. doi:10.3748/wjg.14.6237
  7. 7Cheng J, Gao C, Ala-Jaakkola R, et al. Eight-Week Supplementation With Bifidobacterium lactis HN019 and Functional Constipation: A Randomized Clinical Trial. JAMA Netw Open. 2024;7(10):e2436888. doi:10.1001/jamanetworkopen.2024.36888
  8. 8Nevé BL, Martinez-De la Torre A, Tap J, et al. A Fermented Milk Product Containing B. lactis CNCM I-2494 Improves the Tolerance of a Plant-Based Diet in Patients with Disorders of Gut-Brain Interactions. Nutrients. 2021;13(12). doi:10.3390/nu13124542
  9. 9Zare Javid A, Amerian E, Basir L, Ekrami A, Haghighizadeh MH, Maghsoumi-Norouzabad L. Effects of the Consumption of Probiotic Yogurt Containing Bifidobacterium lactis Bb12 on the Levels of Streptococcus mutans and Lactobacilli in Saliva of Students with Initial Stages of Dental Caries: A Double-Blind Randomized Controlled Trial. Caries Res. 2020;54(1):68-74. doi:10.1159/000504164
  10. 10Bernini LJ, Simão ANC, de Souza CHB, et al. Effect of Bifidobacterium lactis HN019 on inflammatory markers and oxidative stress in subjects with and without the metabolic syndrome. Br J Nutr. 2018;120(6):645-652. doi:10.1017/S0007114518001861
  11. 11Matsumoto M, Benno Y. Consumption of Bifidobacterium lactis LKM512 yogurt reduces gut mutagenicity by increasing gut polyamine contents in healthy adult subjects. Mutat Res. 2004;568(2):147-53. doi:10.1016/j.mrfmmm.2004.07.016
  12. 12Arunachalam K, Gill HS, Chandra RK. Enhancement of natural immune function by dietary consumption of Bifidobacterium lactis (HN019). Eur J Clin Nutr. 2000;54(3):263-7. doi:10.1038/sj.ejcn.1600938
  13. 13Ma C, Huo D, You Z, et al. Differential pattern of indigenous microbiome responses to probiotic Bifidobacterium lactis V9 consumption across subjects. Food Res Int. 2020;136:109496. doi:10.1016/j.foodres.2020.109496
  14. 14Merenstein DJ, Tan TP, Molokin A, et al. Safety of Bifidobacterium animalis subsp. lactis (B. lactis) strain BB-12-supplemented yogurt in healthy adults on antibiotics: a phase I safety study. Gut Microbes. 2015;6(1):66-77. doi:10.1080/19490976.2015.1005484
  15. 15Singh A, Hacini-Rachinel F, Gosoniu ML, et al. Immune-modulatory effect of probiotic Bifidobacterium lactis NCC2818 in individuals suffering from seasonal allergic rhinitis to grass pollen: an exploratory, randomized, placebo-controlled clinical trial. Eur J Clin Nutr. 2013;67(2):161-7. doi:10.1038/ejcn.2012.197
  16. 16Holscher HD, Czerkies LA, Cekola P, et al. Bifidobacterium lactis Bb12 enhances intestinal antibody response in formula-fed infants: a randomized, double-blind, controlled trial. JPEN J Parenter Enteral Nutr. 2012;36(1 Suppl):106S-17S. doi:10.1177/0148607111430817
  17. 17Guyonnet D, Schlumberger A, Mhamdi L, Jakob S, Chassany O. Fermented milk containing Bifidobacterium lactis DN-173 010 improves gastrointestinal well-being and digestive symptoms in women reporting minor digestive symptoms: a randomised, double-blind, parallel, controlled study. Br J Nutr. 2009;102(11):1654-62. doi:10.1017/S0007114509990882
  18. 18Prescott SL, Wickens K, Westcott L, et al. Supplementation with Lactobacillus rhamnosus or Bifidobacterium lactis probiotics in pregnancy increases cord blood interferon-gamma and breast milk transforming growth factor-beta and immunoglobin A detection. Clin Exp Allergy. 2008;38(10):1606-14. doi:10.1111/j.1365-2222.2008.03061.x
  19. 19Caglar E, Kuscu OO, Selvi Kuvvetli S, Kavaloglu Cildir S, Sandalli N, Twetman S. Short-term effect of ice-cream containing Bifidobacterium lactis Bb-12 on the number of salivary mutans streptococci and lactobacilli. Acta Odontol Scand. 2008;66(3):154-8. doi:10.1080/00016350802089467
  20. 20Larsen CN, Nielsen S, Kaestel P, et al. Dose-response study of probiotic bacteria Bifidobacterium animalis subsp lactis BB-12 and Lactobacillus paracasei subsp paracasei CRL-341 in healthy young adults. Eur J Clin Nutr. 2006;60(11):1284-93. doi:10.1038/sj.ejcn.1602450
  21. 21Pakizeh M, Nouri L, Azizi MH. Antimutagenic activity of different forms of Bifidobacterium lactis probiotic against aflatoxin B1 by Ames method. Toxicon. 2024;239:107608. doi:10.1016/j.toxicon.2024.107608
  22. 22Nurmi JT, Puolakkainen PA, Rautonen NE. Bifidobacterium Lactis sp. 420 up-regulates cyclooxygenase (Cox)-1 and down-regulates Cox-2 gene expression in a Caco-2 cell culture model. Nutr Cancer. 2005;51(1):83-92. doi:10.1207/s15327914nc5101_12