Bifidobacterium lactis
What the research shows
Mostly no concerns
most studies in people found no harm or a benefit
A bacterium found in the large intestines of humans.
It is used as a probiotic in products.1
What research says
Studies in people
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No harm found
Infant growth2
Babies fed formula with Bifidobacterium lactis grew the same as babies fed formula without it.
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Open question
Gut transit time3
In people, Bifidobacterium lactis was linked to faster gut transit, but scientists say evidence for health claims is still insufficient.
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Benefit
Gut health in preterm babies4
In preterm babies, Bifidobacterium lactis raised good gut bacteria, but studies were too small to prove it prevents gut disease.
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Benefit
Immune system support5
Bifidobacterium lactis HN019 may help the immune system, but most studies lasted only a few weeks.
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Benefit
Constipation in women6
Women with constipation who drank milk with Bifidobacterium lactis went to the toilet more often and more easily.
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No harm found
Constipation relief7
In people with constipation, Bifidobacterium lactis HN019 did not increase complete spontaneous bowel movements more than placebo.
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Benefit
Gas and bloating8
In people with gut-brain disorders, Bifidobacterium lactis in a fermented milk product for 28 days reduced reported flatulence and gas episodes.
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Benefit
Mouth bacteria and tooth decay9
Students who ate yogurt with Bifidobacterium lactis had fewer decay-causing mouth bacteria in their saliva.
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Benefit
Inflammation and oxidative stress10
People who took Bifidobacterium lactis HN019 in milk for 90 days had lower inflammation and oxidative stress markers.
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Benefit
Gut health in adults11
In healthy adults, eating yogurt with Bifidobacterium lactis raised a gut substance and lowered mutagenicity.
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Benefit
Immune health in older adults12
In older people, drinking milk with Bifidobacterium lactis for six weeks boosted some immune defences.
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Open question
Gut bacteria survival13
Whether Bifidobacterium lactis stays in your gut may depend on the bacteria already living there.
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No harm found
Gut bacteria during antibiotics14
In adults taking antibiotics, eating yogurt with Bifidobacterium lactis caused no more reported side effects than plain yogurt.
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Benefit
Seasonal hay fever symptoms15
People with hay fever taking Bifidobacterium lactis had lower nasal symptom scores than those taking a placebo.
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Benefit
Infant gut immunity16
In infants fed formula with Bifidobacterium lactis, stool IgA rose in some, and immune response after shots rose in cesarean-delivered infants.
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Benefit
Gut comfort in women17
Women who drank milk with Bifidobacterium lactis daily reported better gut comfort, but the effect faded within a week of stopping.
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Benefit
Baby immune development18
In mothers who took Bifidobacterium lactis, early breast milk had more TGF-beta1 and IgA, and babies' cord blood had less sCD14.
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Benefit
Mouth bacteria19
In young adults, eating ice-cream with Bifidobacterium lactis daily may lower levels of mutans streptococci in saliva.
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Concern
Gut bacteria and bowel habits20
Bifidobacterium lactis survived digestion and showed up in stool, and higher doses made stool looser.
Animal and lab studies only
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Benefit
Mould toxin in food21
Bifidobacterium lactis reduced the mutation-causing effect of aflatoxin B1, a mould toxin sometimes found in food.
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Open question
Gut inflammation and cancer22
In lab studies, Bifidobacterium lactis raised Cox-1 and lowered Cox-2 in gut cells, but the authors only suggest this may matter.
The signal at the top counts the findings in people and in animal and lab studies. A concern in studies of people outranks animal and lab studies, and “No concerns” needs at least one finding in people. When most findings in people point one way, the page leans that way (“Mostly”), and every finding is still shown. Findings whose study type is not stated are shown but not counted. This page is a reference, not medical advice. It describes what regulators and published research say. Talk to a doctor or dietitian about your own diet.
Products
The 6 most-scanned of 530 products on Open Food Facts that list bifidobacterium lactis.
- Fermented Coconut Yoghurt Alternative The Coconut Collab · 350 g 1 additive
- KEFIR YOGURT Passion Fruit Mango and Papaya Graham's · 350 g 0 additives
- organic supergreens fruits & vegetables zena greens 4 additives
- Activia Strawberry Yogurt Danone 1 additive
- GREEK NONFAT YOGURT PLAIN TRADER JOE'S · 2 lb (907 g) 0 additives
- simple ingredient skyr PLAIN siggi's 0 additives
References
- 1Bifidobacterium lactis: ingredient taxonomy entry. Open Food Facts.
- 2Szajewska H, Chmielewska A. Growth of infants fed formula supplemented with Bifidobacterium lactis Bb12 or Lactobacillus GG: a systematic review of randomized controlled trials. BMC Pediatr. 2013;13:185. doi:10.1186/1471-2431-13-185
- 3Meléndez-Illanes L, González-Díaz C, Chilet-Rosell E, Álvarez-Dardet C. Does the scientific evidence support the advertising claims made for products containing Lactobacillus casei and Bifidobacterium lactis? A systematic review. J Public Health (Oxf). 2016;38(3):e375-e383. doi:10.1093/pubmed/fdv151
- 4Szajewska H, Guandalini S, Morelli L, Van Goudoever JB, Walker A. Effect of Bifidobacterium animalis subsp lactis supplementation in preterm infants: a systematic review of randomized controlled trials. J Pediatr Gastroenterol Nutr. 2010;51(2):203-9. doi:10.1097/MPG.0b013e3181dc0d93
- 5Sanders ME. Summary of probiotic activities of Bifidobacterium lactis HN019. J Clin Gastroenterol. 2006;40(9):776-83. doi:10.1097/01.mcg.0000225576.73385.f0
- 6Yang YX, He M, Hu G, et al. Effect of a fermented milk containing Bifidobacterium lactis DN-173010 on Chinese constipated women. World J Gastroenterol. 2008;14(40):6237-43. doi:10.3748/wjg.14.6237
- 7Cheng J, Gao C, Ala-Jaakkola R, et al. Eight-Week Supplementation With Bifidobacterium lactis HN019 and Functional Constipation: A Randomized Clinical Trial. JAMA Netw Open. 2024;7(10):e2436888. doi:10.1001/jamanetworkopen.2024.36888
- 8Nevé BL, Martinez-De la Torre A, Tap J, et al. A Fermented Milk Product Containing B. lactis CNCM I-2494 Improves the Tolerance of a Plant-Based Diet in Patients with Disorders of Gut-Brain Interactions. Nutrients. 2021;13(12). doi:10.3390/nu13124542
- 9Zare Javid A, Amerian E, Basir L, Ekrami A, Haghighizadeh MH, Maghsoumi-Norouzabad L. Effects of the Consumption of Probiotic Yogurt Containing Bifidobacterium lactis Bb12 on the Levels of Streptococcus mutans and Lactobacilli in Saliva of Students with Initial Stages of Dental Caries: A Double-Blind Randomized Controlled Trial. Caries Res. 2020;54(1):68-74. doi:10.1159/000504164
- 10Bernini LJ, Simão ANC, de Souza CHB, et al. Effect of Bifidobacterium lactis HN019 on inflammatory markers and oxidative stress in subjects with and without the metabolic syndrome. Br J Nutr. 2018;120(6):645-652. doi:10.1017/S0007114518001861
- 11Matsumoto M, Benno Y. Consumption of Bifidobacterium lactis LKM512 yogurt reduces gut mutagenicity by increasing gut polyamine contents in healthy adult subjects. Mutat Res. 2004;568(2):147-53. doi:10.1016/j.mrfmmm.2004.07.016
- 12Arunachalam K, Gill HS, Chandra RK. Enhancement of natural immune function by dietary consumption of Bifidobacterium lactis (HN019). Eur J Clin Nutr. 2000;54(3):263-7. doi:10.1038/sj.ejcn.1600938
- 13Ma C, Huo D, You Z, et al. Differential pattern of indigenous microbiome responses to probiotic Bifidobacterium lactis V9 consumption across subjects. Food Res Int. 2020;136:109496. doi:10.1016/j.foodres.2020.109496
- 14Merenstein DJ, Tan TP, Molokin A, et al. Safety of Bifidobacterium animalis subsp. lactis (B. lactis) strain BB-12-supplemented yogurt in healthy adults on antibiotics: a phase I safety study. Gut Microbes. 2015;6(1):66-77. doi:10.1080/19490976.2015.1005484
- 15Singh A, Hacini-Rachinel F, Gosoniu ML, et al. Immune-modulatory effect of probiotic Bifidobacterium lactis NCC2818 in individuals suffering from seasonal allergic rhinitis to grass pollen: an exploratory, randomized, placebo-controlled clinical trial. Eur J Clin Nutr. 2013;67(2):161-7. doi:10.1038/ejcn.2012.197
- 16Holscher HD, Czerkies LA, Cekola P, et al. Bifidobacterium lactis Bb12 enhances intestinal antibody response in formula-fed infants: a randomized, double-blind, controlled trial. JPEN J Parenter Enteral Nutr. 2012;36(1 Suppl):106S-17S. doi:10.1177/0148607111430817
- 17Guyonnet D, Schlumberger A, Mhamdi L, Jakob S, Chassany O. Fermented milk containing Bifidobacterium lactis DN-173 010 improves gastrointestinal well-being and digestive symptoms in women reporting minor digestive symptoms: a randomised, double-blind, parallel, controlled study. Br J Nutr. 2009;102(11):1654-62. doi:10.1017/S0007114509990882
- 18Prescott SL, Wickens K, Westcott L, et al. Supplementation with Lactobacillus rhamnosus or Bifidobacterium lactis probiotics in pregnancy increases cord blood interferon-gamma and breast milk transforming growth factor-beta and immunoglobin A detection. Clin Exp Allergy. 2008;38(10):1606-14. doi:10.1111/j.1365-2222.2008.03061.x
- 19Caglar E, Kuscu OO, Selvi Kuvvetli S, Kavaloglu Cildir S, Sandalli N, Twetman S. Short-term effect of ice-cream containing Bifidobacterium lactis Bb-12 on the number of salivary mutans streptococci and lactobacilli. Acta Odontol Scand. 2008;66(3):154-8. doi:10.1080/00016350802089467
- 20Larsen CN, Nielsen S, Kaestel P, et al. Dose-response study of probiotic bacteria Bifidobacterium animalis subsp lactis BB-12 and Lactobacillus paracasei subsp paracasei CRL-341 in healthy young adults. Eur J Clin Nutr. 2006;60(11):1284-93. doi:10.1038/sj.ejcn.1602450
- 21Pakizeh M, Nouri L, Azizi MH. Antimutagenic activity of different forms of Bifidobacterium lactis probiotic against aflatoxin B1 by Ames method. Toxicon. 2024;239:107608. doi:10.1016/j.toxicon.2024.107608
- 22Nurmi JT, Puolakkainen PA, Rautonen NE. Bifidobacterium Lactis sp. 420 up-regulates cyclooxygenase (Cox)-1 and down-regulates Cox-2 gene expression in a Caco-2 cell culture model. Nutr Cancer. 2005;51(1):83-92. doi:10.1207/s15327914nc5101_12