Dextrose meal and adiponectin response in older women
What it found
In older women, adiponectin rose after a dextrose drink but fell after a high-fat meal.
Younger women showed no change after either meal.
What they found
Studies in people
Adiponectin after meals
In younger women, adiponectin stayed stable after both test meals. In older women, it rose after dextrose and fell after the high-fat meal.
Age group differences
The differences between older and younger women were partly explained by metabolic measures and oxidative stress.
Links with other markers
After dextrose, adiponectin was positively linked with malondialdehyde and inversely linked with interleukin-6. It was also negatively linked with metabolic measures after both meals.
FGF21 and adiponectin
In older women, higher FGF21 levels after the meal were linked with a higher adiponectin response.
What the authors conclude
“Adiponectin response is associated with type of dietary challenge, age, and FGF21 response.”
Also in their conclusions
- They conclude that the adiponectin response is associated with the type of dietary challenge, age, and FGF21 response.
- They state that age-group differences are partly attributable to metabolic parameters and oxidative stress.
How it was done
Higher adiponectin levels have been linked with death in older age, and little is known about how adiponectin changes after meals in older adults.
Older women (n = 20) and younger women (n = 22) were randomly given a dextrose or high-fat dietary challenge. Adiponectin and FGF21 were measured before and 60, 120 and 240 minutes after eating.
What it can’t tell you
- We summarised it from the abstract only.
- This trial was small, with 20 older and 22 younger women, so the results may not apply to all people.
- It only looked at one dextrose drink and one high-fat meal, so it cannot show what happens with usual eating over time.
Who paid
- Authors work at
- German Institute of Human Nutrition, Germany; University of Potsdam, Germany; German Center for Diabetes Research (DZD), Germany
The paper
- Title
- Altered Adiponectin Response in Older Women Following Dextrose and High-Fat Dietary Challenges
- Type
- Randomised controlled trial
- Evidence
- Studies in people
- Summarised from
- Abstract only
- Cite
- Herpich C, Kochlik B, Haß U, Weber D, Grune T, Norman K (2021). Altered Adiponectin Response in Older Women Following Dextrose and High-Fat Dietary Challenges. Molecular nutrition & food research. doi:10.1002/mnfr.202100487PubMed 34288404DOI
Summary written 26 Sep 2026. Check it against the paper before it changes what you eat. How we summarise papers · Report an error